| 1 | Tue Nov 5 | vs UMass Lowell | W79-64 | 1-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Sat Nov 9 | atFairfield | W62-60 | 2-0 | 1.000 | - | | Leo D. Mahoney Arena · Fairfield, CT |
| 3 | Tue Nov 12 | vsNortheastern | W80-71 | 3-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 4 | Sat Nov 16 | vsC Connecticut | W89-43 | 4-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Wed Nov 20 | vsRider | W82-72 | 5-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 6 | Sat Nov 23 | atVirginia | L46-58 | 5-1 | .833 | - | ESPNEWS | John Paul Jones Arena · Charlottesville, VA |
| 7 | Sun Nov 24 | atSt John's | L63-78 | 5-2 | .714 | - | ESPN2 | Carnesecca Arena · Queens, NY |
| 8 | Fri Nov 29 | atRutgers | L57-82 | 5-3 | .625 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Wed Dec 4 | vsSouth Carolina | L80-84 | 5-4 | .556 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Sat Dec 7 | atHarvard | L55-89 | 5-5 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 11 | Wed Dec 11 | vsYale | L80-83 (OT) | 5-6 | .455 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Fri Dec 20 | vsMaine | W74-53 | 6-6 | .500 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Mon Dec 30 | atAkron | L79-85 | 6-7 | .462 | - | | James A. Rhodes Arena · Akron, OH |
| 14 | Sun Jan 5 | atSaint Louis | L80-83 (OT) | 6-8 | .429 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 15 | Wed Jan 8 | vsLa Salle | W77-69 | 7-8 | .467 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Sat Jan 11 | at#15Dayton | L60-88 | 7-9 | .438 | - | NBCSN | UD Arena · Dayton, OH |
| 17 | Wed Jan 15 | atSt Bonaventure | L61-74 | 7-10 | .412 | - | | Reilly Center · Saint Bonaventure, NY |
| 18 | Sat Jan 18 | vsG Washington | L51-75 | 7-11 | .389 | - | NBCSN | William D. Mullins Memorial Center · Amherst, MA |
| 19 | Wed Jan 22 | atGeorge Mason | L63-73 | 7-12 | .368 | - | | EagleBank Arena · Fairfax, VA |
| 20 | Sat Jan 25 | vsDuquesne | W73-64 | 8-12 | .400 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 21 | Wed Jan 29 | vsSaint Joseph's | W91-76 | 9-12 | .429 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 22 | Sat Feb 1 | atDavidson | L50-85 | 9-13 | .409 | - | CBS | John M. Belk Arena · Davidson, NC |
| 23 | Tue Feb 4 | atRhode Island | L67-73 | 9-14 | .391 | - | CBS | Ryan Center · Kingston, RI |
| 24 | Sun Feb 9 | vsGeorge Mason | W69-67 | 10-14 | .417 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 25 | Sat Feb 15 | vs#6Dayton | L63-71 | 10-15 | .400 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 26 | Tue Feb 18 | vsSaint Louis | W67-63 | 11-15 | .423 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Sat Feb 22 | atFordham | W57-49 | 12-15 | .444 | - | | Rose Hill Gymnasium · Bronx, NY |
| 28 | Wed Feb 26 | vsVCU | W60-52 | 13-15 | .464 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 29 | Sat Feb 29 | atRichmond | L71-95 | 13-16 | .448 | - | | Robins Center · Richmond, VA |
| 30 | Wed Mar 4 | atLa Salle | W75-64 | 14-16 | .467 | - | | Tom Gola Arena · Philadelphia, PA |
| 31 | Sat Mar 7 | vsRhode Island | L63-64 | 14-17 | .452 | - | | William D. Mullins Memorial Center · Amherst, MA |
