| 1 | Tue Nov 7 | vs Albany | W92-71 | 1-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Mon Nov 13 | vsQuinnipiac | W102-81 | 2-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 3 | Fri Nov 17 | vsHarvard | L75-78 (OT) | 2-1 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 4 | Wed Nov 22 | vsC Connecticut | W89-60 | 3-1 | .750 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Sat Dec 2 | vsSouth Florida | W66-56 | 4-1 | .800 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 6 | Wed Dec 6 | atTowson | L71-81 | 4-2 | .667 | - | | SECU Arena · Towson, MD |
| 7 | Sat Dec 9 | vsUMass Lowell | W91-77 | 5-2 | .714 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 8 | Sat Dec 16 | vsWest Virginia | W87-79 | 6-2 | .750 | - | ESPNU | William D. Mullins Memorial Center · Amherst, MA |
| 9 | Thu Dec 21 | vsGeorgia Tech | L70-73 | 6-3 | .667 | - | ESPN2 | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Sat Dec 23 | atPortland | W100-78 | 7-3 | .700 | - | ESPN2 | Chiles Center · Portland, OR |
| 11 | Sun Dec 24 | vsOld Dominion | W87-65 | 8-3 | .727 | - | ESPN2 | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Sat Dec 30 | vsSiena | W79-66 | 9-3 | .750 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Wed Jan 3 | vsDuquesne | W80-61 | 10-3 | .769 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Sun Jan 7 | atDayton | L60-64 | 10-4 | .714 | - | ESPN2 | UD Arena · Dayton, OH |
| 15 | Wed Jan 10 | vsLa Salle | W81-65 | 11-4 | .733 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Sat Jan 13 | atRhode Island | L77-89 | 11-5 | .688 | - | | Ryan Center · Kingston, RI |
| 17 | Wed Jan 17 | atLoyola Chicago | L78-79 | 11-6 | .647 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Sat Jan 20 | vsG Washington | W81-67 | 12-6 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 19 | Tue Jan 23 | vsSaint Joseph's | L77-78 | 12-7 | .632 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Sat Jan 27 | atSaint Louis | W84-73 | 13-7 | .650 | - | | Chaifetz Arena · St. Louis, MO |
| 21 | Sat Feb 3 | vsGeorge Mason | W66-65 | 14-7 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 22 | Wed Feb 7 | atSt Bonaventure | L73-79 | 14-8 | .636 | - | | Reilly Center · Saint Bonaventure, NY |
| 23 | Sun Feb 11 | vsRhode Island | W81-79 | 15-8 | .652 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Wed Feb 14 | atRichmond | W69-59 | 16-8 | .667 | - | | Robins Center · Richmond, VA |
| 25 | Sat Feb 17 | atLa Salle | L81-82 | 16-9 | .640 | - | | Tom Gola Arena · Philadelphia, PA |
| 26 | Tue Feb 20 | vsVCU | W74-52 | 17-9 | .654 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Sat Feb 24 | vsSt Bonaventure | L67-75 | 17-10 | .630 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 28 | Tue Feb 27 | atG Washington | W69-57 | 18-10 | .643 | - | | Charles E. Smith Center · Washington, D.C. |
| 29 | Sat Mar 2 | atDavidson | W69-67 | 19-10 | .655 | - | USA Net | John M. Belk Arena · Davidson, NC |
| 30 | Wed Mar 6 | vsFordham | W66-64 | 20-10 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 31 | Thu Mar 14 | vsVCU | L59-73 | 20-11 | .645 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
