| 1 | Tue Nov 9 | vs UMBC | W77-60 | 1-0 | 1.000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Fri Nov 12 | atYale | L71-91 | 1-1 | .500 | - | | John J. Lee Amphitheater · New Haven, CT |
| 3 | Mon Nov 15 | vsPenn State | W81-56 | 2-1 | .667 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 4 | Thu Nov 18 | atWeber St | L73-88 | 2-2 | .500 | - | CBS | Dee Events Center · Ogden, UT |
| 5 | Fri Nov 19 | vsUNC Greensboro | W93-90 (OT) | 3-2 | .600 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 6 | Sun Nov 21 | vsBall State | L86-89 | 3-3 | .500 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 7 | Wed Nov 24 | vsUMass Lowell | W92-81 | 4-3 | .571 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 8 | Sat Nov 27 | vsRutgers | W85-83 | 5-3 | .625 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 9 | Sat Dec 4 | vsHarvard | W87-77 | 6-3 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Tue Dec 7 | atNortheastern | L76-82 | 6-4 | .600 | - | | Matthews Arena · Boston, MA |
| 11 | Sat Dec 11 | vsNorth Texas | L57-66 | 6-5 | .545 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Sun Dec 19 | vsFairfield | W77-73 (OT) | 7-5 | .583 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Thu Dec 30 | vsSaint Louis | PPD | 15-17 | .469 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 15 | Sun Jan 2 | atFordham | PPD | 15-17 | .469 | - | | Rose Hill Gymnasium · Bronx, NY |
| 16 | Wed Jan 5 | atRichmond | L72-80 | 7-6 | .538 | - | | Robins Center · Richmond, VA |
| 17 | Sat Jan 8 | vsDuquesne | L74-78 | 7-7 | .500 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 18 | Tue Jan 11 | atDavidson | L67-77 | 7-8 | .467 | - | | John M. Belk Arena · Davidson, NC |
| 19 | Sat Jan 15 | vsRhode Island | L68-81 | 7-9 | .438 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Thu Jan 20 | vsSaint Louis | W91-85 | 8-9 | .471 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 21 | Sun Jan 23 | atSaint Louis | L59-90 | 8-10 | .444 | - | | Chaifetz Arena · St. Louis, MO |
| 22 | Wed Jan 26 | atLa Salle | W77-71 | 9-10 | .474 | - | | Tom Gola Arena · Philadelphia, PA |
| 23 | Sun Jan 30 | vsGeorge Mason | L62-72 | 9-11 | .450 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Sat Feb 5 | atRhode Island | W78-67 | 10-11 | .476 | - | | Ryan Center · Kingston, RI |
| 25 | Wed Feb 9 | vsG Washington | L68-77 | 10-12 | .455 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 26 | Sat Feb 12 | vsSaint Joseph's | W69-67 | 11-12 | .478 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Wed Feb 16 | atSt Bonaventure | L71-83 | 11-13 | .458 | - | | Reilly Center · Saint Bonaventure, NY |
| 28 | Sat Feb 19 | vsLa Salle | W80-74 | 12-13 | .480 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 29 | Wed Feb 23 | atDayton | L61-82 | 12-14 | .462 | - | | UD Arena · Dayton, OH |
| 30 | Sat Feb 26 | vsVCU | L62-77 | 12-15 | .444 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 31 | Mon Feb 28 | atFordham | L73-85 | 12-16 | .429 | - | | Rose Hill Gymnasium · Bronx, NY |
| 32 | Wed Mar 2 | vsFordham | W81-73 | 13-16 | .448 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 33 | Sat Mar 5 | atGeorge Mason | W83-80 (OT) | 14-16 | .467 | - | | EagleBank Arena · Fairfax, VA |
| 34 | Thu Mar 10 | atG Washington | W99-88 | 15-16 | .484 | - | USA Net | Charles E. Smith Center · Washington, D.C. |
| 35 | Fri Mar 11 | atDayton | L72-75 | 15-17 | .469 | - | USA Net | UD Arena · Dayton, OH |
