| 1 | Tue Nov 4 | vs TBD | W88-70 | 1-0 | 1.000 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 2 | Sat Nov 8 | vsTBD | W106-57 | 2-0 | 1.000 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 3 | Tue Nov 11 | vsArkansas St | L85-86 | 2-1 | .667 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 4 | Sat Nov 15 | atUT Arlington | L49-67 | 2-2 | .500 | - | ESPN+ | College Park Center · Arlington, TX |
| 5 | Sat Nov 22 | vsUT Rio Grande | W74-67 | 3-2 | .600 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 6 | Mon Nov 24 | vsLong Island | L61-75 | 3-3 | .500 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 7 | Sun Nov 30 | vsTBD | W92-71 | 4-3 | .571 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 8 | Sat Dec 6 | atTulsa | L74-98 | 4-4 | .500 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 9 | Fri Dec 12 | atXavier | L57-75 | 4-5 | .444 | - | truTV | Cintas Center · Cincinnati, OH |
| 10 | Tue Dec 16 | vsOral Roberts | W63-62 | 5-5 | .500 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 11 | Tue Dec 23 | vsLindenwood | W70-65 | 6-5 | .545 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 12 | Mon Dec 29 | atDelaware | W61-43 | 7-5 | .583 | - | ESPN+ | Bob Carpenter Center · Newark, DE |
| 13 | Fri Jan 2 | vsUTEP | W79-55 | 8-5 | .615 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 14 | Sun Jan 4 | vsNew Mexico St | W89-82 | 9-5 | .643 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 15 | Wed Jan 7 | atKennesaw St | L80-90 | 9-6 | .600 | - | ESPN+ | KSU Convocation Center · Kennesaw, GA |
| 16 | Sat Jan 10 | vsFIU | W79-71 | 10-6 | .625 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 17 | Wed Jan 14 | atWestern KY | L72-87 | 10-7 | .588 | - | ESPN+ | E. A. Diddle Arena · Bowling Green, KY |
| 18 | Sat Jan 17 | atMTSU | L87-90 (2OT) | 10-8 | .556 | - | ESPN+ | Murphy Center · Murfreesboro, TN |
| 19 | Thu Jan 22 | atNew Mexico St | W84-75 | 11-8 | .579 | - | CBSSN | Pan American Center · Las Cruces, NM |
| 20 | Sat Jan 24 | atUTEP | W62-57 | 12-8 | .600 | - | ESPN+ | Don Haskins Center · El Paso, TX |
| 21 | Wed Jan 28 | vsSam Houston | L71-80 | 12-9 | .571 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 22 | Sat Jan 31 | vsJ'Ville St | W74-67 | 13-9 | .591 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 23 | Sat Feb 7 | atLiberty | L76-79 | 13-10 | .565 | - | CBSSN | Liberty Arena · Lynchburg, VA |
| 24 | Thu Feb 12 | vsLouisiana Tech | L78-79 (2OT) | 13-11 | .542 | - | CBSSN | Great Southern Bank Arena · Springfield, MO |
| 25 | Sat Feb 14 | vsDelaware | L67-76 | 13-12 | .520 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 26 | Wed Feb 18 | vsKennesaw St | L87-91 | 13-13 | .500 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 27 | Sat Feb 21 | atFIU | L67-70 | 13-14 | .481 | - | ESPN+ | Ocean Bank Convocation Center · Miami, FL |
| 28 | Thu Feb 26 | atLouisiana Tech | L70-72 | 13-15 | .464 | - | ESPN+ | Thomas Assembly Center · Ruston, LA |
| 29 | Sat Feb 28 | atSam Houston | L81-86 | 13-16 | .448 | - | ESPN+ | Bernard G. Johnson Coliseum · Huntsville, TX |
