| 1 | Mon Nov 4 | at Butler | L65-72 | 0-1 | .000 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Mon Nov 11 | vs TBD | W90-61 | 1-1 | .500 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 3 | Sat Nov 16 | vs Tulsa | W111-106 (3OT) | 2-1 | .667 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 4 | Tue Nov 19 | vs UT Arlington | W78-68 | 3-1 | .750 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 5 | Sun Nov 24 | at High Point | W71-61 | 4-1 | .800 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 6 | Mon Nov 25 | at Boston College | L74-76 (OT) | 4-2 | .667 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Tue Nov 26 | vs S Dakota St | L55-75 | 4-3 | .571 | - | | Great Southern Bank Arena · Springfield, MO |
| 8 | Sun Dec 1 | at Oral Roberts | W72-67 | 5-3 | .625 | - | | Mabee Center · Tulsa, OK |
| 9 | Sat Dec 7 | vs Indiana St | L77-80 | 5-4 | .556 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 10 | Sat Dec 14 | at Washington St | L78-91 | 5-5 | .500 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 11 | Wed Dec 18 | vsTBD | W61-49 | 6-5 | .545 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 12 | Sun Dec 22 | vs UCSB | W68-56 | 7-5 | .583 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 13 | Sun Dec 29 | at Evansville | L40-57 | 7-6 | .538 | - | ESPN+ | Ford Center · Evansville, IN |
| 14 | Wed Jan 1 | vs Valparaiso | L72-73 | 7-7 | .500 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 15 | Sat Jan 4 | at Bradley | L60-69 | 7-8 | .467 | - | CBS | Carver Arena · Peoria, IL |
| 16 | Tue Jan 7 | vs UIC | L63-80 | 7-9 | .438 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 17 | Sat Jan 11 | at S Illinois | L78-88 (OT) | 7-10 | .412 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 18 | Wed Jan 15 | vsS Illinois | L51-73 | 7-11 | .389 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 19 | Sat Jan 18 | at Illinois St | L68-74 | 7-12 | .368 | - | ESPN+ | Redbird Arena · Normal, IL |
| 20 | Tue Jan 21 | at Northern Iowa | L68-79 | 7-13 | .350 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 21 | Sat Jan 25 | vs Drake | L62-69 (OT) | 7-14 | .333 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 22 | Wed Jan 29 | atIndiana St | L67-72 | 7-15 | .318 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 23 | Sat Feb 1 | vs Murray St | W77-56 | 8-15 | .348 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 24 | Wed Feb 5 | vsNorthern Iowa | L61-66 | 8-16 | .333 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 25 | Sat Feb 8 | at Belmont | L68-85 | 8-17 | .320 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 26 | Wed Feb 12 | vsEvansville | W71-54 | 9-17 | .346 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 27 | Sun Feb 16 | atUIC | L58-63 | 9-18 | .333 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 28 | Wed Feb 19 | atValparaiso | L64-66 | 9-19 | .321 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 29 | Sat Feb 22 | vsIllinois St | L68-70 | 9-20 | .310 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 30 | Wed Feb 26 | vsBelmont | L65-74 | 9-21 | .300 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 31 | Sun Mar 2 | atDrake | L60-68 (OT) | 9-22 | .290 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 32 | Thu Mar 6 | atIllinois St | L54-70 | 9-23 | .281 | - | ESPN+ | Redbird Arena · Normal, IL |
