| 6 | Wed Dec 16 | vs TBD | W73-64 | 1-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 7 | Sat Dec 19 | vsN'Western St | W94-67 | 2-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 8 | Mon Dec 21 | vsLittle Rock | W85-77 | 3-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 9 | Sun Dec 27 | atNorthern Iowa | W79-59 | 4-0 | 1.000 | - | | McLeod Center · Cedar Falls, IA |
| 10 | Mon Dec 28 | atNorthern Iowa | L75-85 | 4-1 | .800 | - | | McLeod Center · Cedar Falls, IA |
| 11 | Sat Jan 2 | vsIndiana St | W84-74 | 5-1 | .833 | - | | Great Southern Bank Arena · Springfield, MO |
| 12 | Sun Jan 3 | vsIndiana St | W70-66 | 6-1 | .857 | - | | Great Southern Bank Arena · Springfield, MO |
| 13 | Sat Jan 9 | atValparaiso | W81-68 | 7-1 | .875 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 14 | Sun Jan 10 | atValparaiso | W78-68 | 8-1 | .889 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 15 | Sun Jan 17 | vsDrake | PPD | 17-7 | .708 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Sun Jan 17 | vsTBD | W94-49 | 9-1 | .900 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Mon Jan 18 | vsDrake | PPD | 17-7 | .708 | - | | Great Southern Bank Arena · Springfield, MO |
| 18 | Tue Jan 26 | vsDrake | L61-68 | 9-2 | .818 | - | | Great Southern Bank Arena · Springfield, MO |
| 19 | Wed Jan 27 | vsDrake | L73-78 | 9-3 | .750 | - | | Great Southern Bank Arena · Springfield, MO |
| 20 | Sun Jan 31 | vsLoyola Chicago | L46-72 | 9-4 | .692 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 21 | Mon Feb 1 | vsLoyola Chicago | L50-70 | 9-5 | .643 | - | | Great Southern Bank Arena · Springfield, MO |
| 22 | Sat Feb 6 | atIllinois St | W74-67 | 10-5 | .667 | - | | Redbird Arena · Normal, IL |
| 23 | Sun Feb 7 | atIllinois St | W72-62 | 11-5 | .688 | - | | Redbird Arena · Normal, IL |
| 24 | Wed Feb 10 | vsS Illinois | W65-53 | 12-5 | .706 | - | | Great Southern Bank Arena · Springfield, MO |
| 25 | Sat Feb 13 | vsBradley | W80-58 | 13-5 | .722 | - | | Great Southern Bank Arena · Springfield, MO |
| 26 | Sun Feb 14 | vsBradley | W72-57 | 14-5 | .737 | - | | Great Southern Bank Arena · Springfield, MO |
| 27 | Wed Feb 17 | atS Illinois | W68-53 | 15-5 | .750 | - | | Banterra Center · Carbondale, IL |
| 28 | Fri Feb 26 | atEvansville | W90-81 | 16-5 | .762 | - | | Ford Center · Evansville, IN |
| 29 | Sat Feb 27 | atEvansville | L63-72 | 16-6 | .727 | - | | Ford Center · Evansville, IN |
| 30 | Fri Mar 5 | vsValparaiso | W66-55 | 17-6 | .739 | - | | Great Southern Bank Arena · Springfield, MO |
| 31 | Sat Mar 6 | atDrake | L69-71 | 17-7 | .708 | - | CBS | The Knapp Center · Des Moines, IA |
