| 1 | Mon Nov 6 | at West Virginia | L59-67 | 0-1 | .000 | - | | WVU Coliseum · Morgantown, WV |
| 2 | Mon Nov 13 | vs Oral Roberts | W84-69 | 1-1 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 3 | Fri Nov 17 | at FGCU | W70-61 | 2-1 | .667 | - | | Alico Arena · Fort Myers, FL |
| 4 | Sun Nov 19 | vs Kent State | W56-52 | 3-1 | .750 | - | | Great Southern Bank Arena · Springfield, MO |
| 5 | Mon Nov 20 | vs Abilene Chrstn | W87-69 | 4-1 | .800 | - | | Great Southern Bank Arena · Springfield, MO |
| 6 | Sat Nov 25 | vs SC State | W92-74 | 5-1 | .833 | - | | Great Southern Bank Arena · Springfield, MO |
| 7 | Wed Nov 29 | vs Evansville | W90-78 | 6-1 | .857 | - | | Great Southern Bank Arena · Springfield, MO |
| 8 | Sat Dec 2 | at Drake | L57-74 | 6-2 | .750 | - | | The Knapp Center · Des Moines, IA |
| 9 | Tue Dec 5 | at MTSU | L73-77 (OT) | 6-3 | .667 | - | | Murphy Center · Murfreesboro, TN |
| 10 | Sat Dec 9 | vs Sam Houston | W69-60 | 7-3 | .700 | - | | Great Southern Bank Arena · Springfield, MO |
| 11 | Sat Dec 16 | at Tulsa | L72-73 | 7-4 | .636 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 12 | Tue Dec 19 | vs Lindenwood | W79-57 | 8-4 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 13 | Sat Dec 23 | at Saint Mary's | W69-64 | 9-4 | .692 | - | | University Credit Union Pavilion · Moraga, CA |
| 14 | Wed Jan 3 | vs Northern Iowa | L62-64 | 9-5 | .643 | - | | Great Southern Bank Arena · Springfield, MO |
| 15 | Sat Jan 6 | at Bradley | L60-86 | 9-6 | .600 | - | | Carver Arena · Peoria, IL |
| 16 | Wed Jan 10 | vs Murray St | L53-77 | 9-7 | .563 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Sat Jan 13 | atEvansville | W74-64 | 10-7 | .588 | - | | Ford Center · Evansville, IN |
| 18 | Tue Jan 16 | at Indiana St | L66-88 | 10-8 | .556 | - | | Hulman Center · Terre Haute, IN |
| 19 | Sat Jan 20 | vs Illinois St | L60-69 | 10-9 | .526 | - | | Great Southern Bank Arena · Springfield, MO |
| 20 | Wed Jan 24 | vsDrake | W83-80 (2OT) | 11-9 | .550 | - | | Great Southern Bank Arena · Springfield, MO |
| 21 | Sat Jan 27 | at Valparaiso | W81-70 | 12-9 | .571 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 22 | Wed Jan 31 | at S Illinois | W76-75 (OT) | 13-9 | .591 | - | | Banterra Center · Carbondale, IL |
| 23 | Sat Feb 3 | vs Belmont | W87-80 | 14-9 | .609 | - | | Great Southern Bank Arena · Springfield, MO |
| 24 | Wed Feb 7 | atNorthern Iowa | L65-72 | 14-10 | .583 | - | | McLeod Center · Cedar Falls, IA |
| 25 | Sat Feb 10 | vsIndiana St | L71-73 | 14-11 | .560 | - | | Great Southern Bank Arena · Springfield, MO |
| 26 | Wed Feb 14 | atMurray St | L72-82 | 14-12 | .538 | - | | CFSB Center · Murray, KY |
| 27 | Sat Feb 17 | vsValparaiso | W82-74 | 15-12 | .556 | - | | Great Southern Bank Arena · Springfield, MO |
| 28 | Wed Feb 21 | vsBradley | L62-86 | 15-13 | .536 | - | | Great Southern Bank Arena · Springfield, MO |
| 29 | Sat Feb 24 | atBelmont | L78-93 | 15-14 | .517 | - | ESPNU | Curb Event Center Arena · Nashville, TN |
| 30 | Wed Feb 28 | atIllinois St | L74-75 | 15-15 | .500 | - | | Redbird Arena · Normal, IL |
| 31 | Sun Mar 3 | vs UIC | W69-59 | 16-15 | .516 | - | | Great Southern Bank Arena · Springfield, MO |
| 32 | Thu Mar 7 | atMurray St | W60-35 | 17-15 | .531 | - | | CFSB Center · Murray, KY |
| 33 | Fri Mar 8 | atIndiana St | L59-75 | 17-16 | .515 | - | | Hulman Center · Terre Haute, IN |
