| 1 | Wed Nov 9 | vs TBD | W82-47 | 1-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 2 | Wed Nov 16 | at BYU | L64-66 | 1-1 | .500 | - | | Marriott Center · Provo, UT |
| 3 | Sat Nov 19 | vs MTSU | W75-51 | 2-1 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 4 | Fri Nov 25 | vs UNC Wilmington | L54-68 | 2-2 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 5 | Sat Nov 26 | at Ball State | L64-67 | 2-3 | .400 | - | | Worthen Arena · Muncie, IN |
| 6 | Sun Nov 27 | vs Oakland | W76-64 | 3-3 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 7 | Wed Nov 30 | at UIC | W66-51 | 4-3 | .571 | - | | Credit Union 1 Arena · Chicago, IL |
| 8 | Sat Dec 3 | vs Bradley | L40-58 | 4-4 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 9 | Wed Dec 7 | at Saint Mary's | L46-66 | 4-5 | .444 | - | | University Credit Union Pavilion · Moraga, CA |
| 10 | Sat Dec 10 | vs Purdue FW | L61-65 | 4-6 | .400 | - | | Great Southern Bank Arena · Springfield, MO |
| 11 | Fri Dec 16 | at Oral Roberts | L77-80 | 4-7 | .364 | - | | Mabee Center · Tulsa, OK |
| 12 | Sun Dec 18 | vs C Michigan | W79-58 | 5-7 | .417 | - | | Great Southern Bank Arena · Springfield, MO |
| 14 | Wed Dec 28 | at Northern Iowa | W79-67 | 6-7 | .462 | - | | McLeod Center · Cedar Falls, IA |
| 15 | Sun Jan 1 | vs Drake | W52-49 | 7-7 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Wed Jan 4 | vs Evansville | W85-62 | 8-7 | .533 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Sat Jan 7 | at Belmont | L61-74 | 8-8 | .500 | - | | Curb Event Center Arena · Nashville, TN |
| 18 | Wed Jan 11 | at Illinois St | L66-76 (OT) | 8-9 | .471 | - | | Redbird Arena · Normal, IL |
| 19 | Sun Jan 15 | vs Indiana St | W64-62 | 9-9 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 20 | Wed Jan 18 | atDrake | W65-62 (OT) | 10-9 | .526 | - | | The Knapp Center · Des Moines, IA |
| 21 | Sat Jan 21 | vs S Illinois | L57-61 | 10-10 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 22 | Tue Jan 24 | vsUIC | W63-59 | 11-10 | .524 | - | | Great Southern Bank Arena · Springfield, MO |
| 23 | Sat Jan 28 | at Murray St | L71-74 | 11-11 | .500 | - | | CFSB Center · Murray, KY |
| 24 | Wed Feb 1 | vs Valparaiso | W76-67 (OT) | 12-11 | .522 | - | | Great Southern Bank Arena · Springfield, MO |
| 25 | Sun Feb 5 | atS Illinois | L53-73 | 12-12 | .500 | - | | Banterra Center · Carbondale, IL |
| 26 | Wed Feb 8 | vsBelmont | W61-59 | 13-12 | .520 | - | | Great Southern Bank Arena · Springfield, MO |
| 27 | Sun Feb 12 | atEvansville | W66-60 | 14-12 | .538 | - | | Ford Center · Evansville, IN |
| 28 | Wed Feb 15 | atBradley | L54-64 | 14-13 | .519 | - | | Carver Arena · Peoria, IL |
| 29 | Sat Feb 18 | vsNorthern Iowa | L66-69 | 14-14 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 30 | Tue Feb 21 | vsMurray St | W84-69 | 15-14 | .517 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 31 | Sun Feb 26 | atIndiana St | W66-62 | 16-14 | .533 | - | | Hulman Center · Terre Haute, IN |
| 32 | Thu Mar 2 | vsUIC | W74-57 | 17-14 | .548 | - | | Great Southern Bank Arena · Springfield, MO |
| 33 | Fri Mar 3 | atS Illinois | L51-54 | 17-15 | .531 | - | | Banterra Center · Carbondale, IL |
Sam Houston