| 1 | Mon Nov 4 | vs TBD | W99-47 | 1-0 | 1.000 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 2 | Fri Nov 8 | at UCF | L68-75 | 1-1 | .500 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 3 | Tue Nov 12 | vs Bethune | W91-69 | 2-1 | .667 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 4 | Sat Nov 16 | vs So Indiana | W93-74 | 3-1 | .750 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 5 | Wed Nov 20 | at Penn State | L89-102 | 3-2 | .600 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 6 | Mon Nov 25 | vs Drexel | W87-81 | 4-2 | .667 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 7 | Tue Nov 26 | vs Radford | L56-69 | 4-3 | .571 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Sat Nov 30 | at E Texas A&M | W77-57 | 5-3 | .625 | - | ESPN+ | The Field House · Commerce, TX |
| 9 | Thu Dec 5 | at Detroit Mercy | L78-79 | 5-4 | .556 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 10 | Sun Dec 8 | vs Robert Morris | W82-77 | 6-4 | .600 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 11 | Wed Dec 11 | vs IU Indy | W78-76 | 7-4 | .636 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Sun Dec 15 | at E Michigan | W99-76 | 8-4 | .667 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 13 | Fri Dec 20 | vsTBD | W103-52 | 9-4 | .692 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 14 | Sun Dec 22 | at #24Michigan | L58-89 | 9-5 | .643 | - | B1G+ | Crisler Center · Ann Arbor, MI |
| 15 | Sun Dec 29 | at Green Bay | W83-67 | 10-5 | .667 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 16 | Wed Jan 1 | at N Kentucky | L68-69 (OT) | 10-6 | .625 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 17 | Sat Jan 4 | vs Youngstown St | W90-81 | 11-6 | .647 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Wed Jan 8 | vs Milwaukee | W78-73 | 12-6 | .667 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 19 | Sat Jan 11 | vsDetroit Mercy | W90-67 | 13-6 | .684 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Wed Jan 15 | at Wright St | W120-113 (2OT) | 14-6 | .700 | - | ESPN+ | Nutter Center · Dayton, OH |
| 21 | Wed Jan 22 | at Oakland | L72-76 | 14-7 | .667 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 25 | atIU Indy | W91-80 | 15-7 | .682 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 23 | Thu Jan 30 | vs Cleveland St | L58-68 | 15-8 | .652 | - | ESPNU | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sun Feb 2 | atMilwaukee | W81-79 | 16-8 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 25 | Wed Feb 5 | vsWright St | W87-64 | 17-8 | .680 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Sat Feb 8 | vsGreen Bay | W89-74 | 18-8 | .692 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 27 | Wed Feb 12 | atYoungstown St | L71-93 | 18-9 | .667 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 28 | Sat Feb 15 | atRobert Morris | L69-76 | 18-10 | .643 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
