| 1 | Tue Nov 9 | vs TBD | W103-54 | 1-0 | 1.000 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 2 | Tue Nov 16 | vs Austin Peay | W65-60 | 2-0 | 1.000 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 3 | Fri Nov 19 | at Minnesota | L49-78 | 2-1 | .667 | - | | Williams Arena · Minneapolis, MN |
| 4 | Fri Nov 26 | vs SE Louisiana | W74-66 | 3-1 | .750 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 5 | Sat Nov 27 | at W Michigan | L85-93 (OT) | 3-2 | .600 | - | | University Arena (MI) · Kalamazoo, MI |
| 6 | Sun Nov 28 | at FGCU | L78-85 | 3-3 | .500 | - | | Alico Arena · Fort Myers, FL |
| 7 | Thu Dec 2 | vs Wright St | L73-86 | 3-4 | .429 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Sat Dec 4 | vs N Kentucky | W71-57 | 4-4 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Wed Dec 8 | at SIUE | L59-80 | 4-5 | .444 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 10 | Sat Dec 11 | vs SE Missouri St | W78-65 | 5-5 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Thu Dec 30 | at Cleveland St | L81-90 | 5-6 | .455 | - | | Wolstein Center · Cleveland, OH |
| 14 | Wed Jan 5 | atCleveland St | L58-65 | 5-7 | .417 | - | | Wolstein Center · Cleveland, OH |
| 15 | Fri Jan 7 | at Youngstown St | W71-61 | 6-7 | .462 | - | | Beeghly Center · Youngstown, OH |
| 16 | Sun Jan 9 | at Robert Morris | W76-70 | 7-7 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 17 | Thu Jan 13 | vs Detroit Mercy | W62-60 | 8-7 | .533 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Sat Jan 15 | vs Oakland | L68-76 | 8-8 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 19 | Mon Jan 17 | vsTBD | W102-59 | 9-8 | .529 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Fri Jan 21 | vsRobert Morris | W86-62 | 10-8 | .556 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 21 | Sun Jan 23 | vsYoungstown St | W82-71 | 11-8 | .579 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 22 | Fri Jan 28 | atN Kentucky | L49-59 | 11-9 | .550 | - | | Truist Arena · Highland Heights, KY |
| 23 | Sun Jan 30 | atWright St | L63-75 | 11-10 | .524 | - | | Nutter Center · Dayton, OH |
| 24 | Fri Feb 4 | vs Milwaukee | W70-60 | 12-10 | .545 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Sun Feb 6 | vs Green Bay | W71-55 | 13-10 | .565 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Thu Feb 10 | vs IU Indy | W72-57 | 14-10 | .583 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 27 | Sat Feb 12 | vs UIC | W73-66 | 15-10 | .600 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 28 | Mon Feb 14 | vsCleveland St | W102-98 (3OT) | 16-10 | .615 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 29 | Fri Feb 18 | atGreen Bay | W74-55 | 17-10 | .630 | - | | Resch Center · Ashwaubenon, WI |
| 30 | Sun Feb 20 | atMilwaukee | W81-71 | 18-10 | .643 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 31 | Thu Feb 24 | atOakland | W81-70 | 19-10 | .655 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Sat Feb 26 | atDetroit Mercy | W81-78 | 20-10 | .667 | - | | Calihan Hall · Detroit, MI |
| 33 | Thu Mar 3 | vsUIC | W78-72 | 21-10 | .677 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 34 | Mon Mar 7 | vsN Kentucky | L43-57 | 21-11 | .656 | - | ESPN2 | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 35 | Sat Mar 19 | vs Drake | L65-87 | 21-12 | .636 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
