| 1 | Mon Nov 4 | at West Virginia | L59-87 | 0-1 | .000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 2 | Thu Nov 7 | at Delaware | L77-81 | 0-2 | .000 | - | FloSports | Bob Carpenter Center · Newark, DE |
| 3 | Sun Nov 10 | vs TBD | W79-51 | 1-2 | .333 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 4 | Thu Nov 14 | vs Stonehill | W63-51 | 2-2 | .500 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 5 | Fri Nov 15 | vs Lindenwood | W67-53 | 3-2 | .600 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 6 | Sun Nov 17 | vs New Orleans | W73-62 | 4-2 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 7 | Thu Nov 21 | at Cornell | W86-76 | 5-2 | .714 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 8 | Wed Nov 27 | vs Canisius | W72-64 | 6-2 | .750 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 9 | Sat Nov 30 | at Ohio | L68-84 | 6-3 | .667 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 10 | Wed Dec 4 | vs Youngstown St | L58-72 | 6-4 | .600 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 11 | Sun Dec 8 | at Purdue FW | L77-82 | 6-5 | .545 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Tue Dec 17 | vs Towson | W68-67 | 7-5 | .583 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 13 | Sat Dec 21 | vs St Francis PA | W90-77 | 8-5 | .615 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 14 | Sun Dec 29 | vs N Kentucky | W97-93 (3OT) | 9-5 | .643 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 15 | Thu Jan 2 | at Detroit Mercy | L76-78 (OT) | 9-6 | .600 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 16 | Sat Jan 4 | at Oakland | W79-71 | 10-6 | .625 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 17 | Wed Jan 8 | vs Cleveland St | L69-80 | 10-7 | .588 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 18 | Sun Jan 12 | vs Wright St | W75-72 | 11-7 | .611 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 19 | Fri Jan 17 | at Green Bay | W89-67 | 12-7 | .632 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 20 | Sun Jan 19 | at Milwaukee | W81-79 | 13-7 | .650 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Wed Jan 22 | atYoungstown St | W72-70 | 14-7 | .667 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 22 | Sat Jan 25 | vsOakland | W73-71 | 15-7 | .682 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 23 | Thu Jan 30 | vs IU Indy | W106-53 | 16-7 | .696 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 24 | Sun Feb 2 | atWright St | L64-66 | 16-8 | .667 | - | ESPN+ | Nutter Center · Dayton, OH |
| 25 | Wed Feb 5 | vsDetroit Mercy | W71-56 | 17-8 | .680 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 26 | Sat Feb 8 | atN Kentucky | W81-76 | 18-8 | .692 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 27 | Wed Feb 12 | atCleveland St | W68-59 | 19-8 | .704 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 28 | Sat Feb 15 | vsPurdue FW | W76-69 | 20-8 | .714 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 29 | Fri Feb 21 | vsGreen Bay | W94-85 | 21-8 | .724 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 30 | Sun Feb 23 | vsMilwaukee | W72-59 | 22-8 | .733 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 31 | Thu Feb 27 | atIU Indy | W82-68 | 23-8 | .742 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Thu Mar 6 | vsWright St | W83-62 | 24-8 | .750 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 33 | Mon Mar 10 | vsOakland | W79-76 (OT) | 25-8 | .758 | - | ESPNU | UPMC Events Center · Moon Township, PA |
| 34 | Tue Mar 11 | vsYoungstown St | W89-78 | 26-8 | .765 | - | ESPN | UPMC Events Center · Moon Township, PA |
| 35 | Fri Mar 21 | at #2Alabama | L81-90 | 26-9 | .743 | #15 | truTV | Coleman Coliseum · Tuscaloosa, AL |
