| 1 | Mon Nov 7 | at Ohio State | L53-91 | 0-1 | .000 | - | | Value City Arena · Columbus, OH |
| 2 | Wed Nov 9 | vsTBD | W84-49 | 1-1 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 3 | Wed Nov 16 | vsTBD | W111-56 | 2-1 | .667 | - | | UPMC Events Center · Moon Township, PA |
| 4 | Sat Nov 19 | at#21Dayton | L51-60 | 2-2 | .500 | - | | UD Arena · Dayton, OH |
| 5 | Fri Nov 25 | atMercer | L66-72 | 2-3 | .400 | - | | Hawkins Arena · Macon, GA |
| 6 | Sat Nov 26 | atEvansville | L53-54 | 2-4 | .333 | - | | Ford Center · Evansville, IN |
| 7 | Sun Nov 27 | vsSouth Alabama | L70-84 | 2-5 | .286 | - | | UPMC Events Center · Moon Township, PA |
| 8 | Thu Dec 1 | atWright St | W80-59 | 3-5 | .375 | - | | Nutter Center · Dayton, OH |
| 9 | Sat Dec 3 | atN Kentucky | L56-60 | 3-6 | .333 | - | | Truist Arena · Highland Heights, KY |
| 10 | Wed Dec 7 | atC Michigan | W71-66 | 4-6 | .400 | - | | McGuirk Arena · Mount Pleasant, MI |
| 11 | Sat Dec 10 | vsMarshall | L60-69 | 4-7 | .364 | - | | UPMC Events Center · Moon Township, PA |
| 12 | Sun Dec 18 | atMount St Mary | W68-59 | 5-7 | .417 | - | | Knott Arena · Emmitsburg, MD |
| 13 | Wed Dec 21 | vsSt Francis PA | W77-66 | 6-7 | .462 | - | | UPMC Events Center · Moon Township, PA |
| 14 | Thu Dec 29 | vsPurdue FW | W75-70 | 7-7 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 15 | Sat Dec 31 | vsCleveland St | L54-63 | 7-8 | .467 | - | | UPMC Events Center · Moon Township, PA |
| 16 | Thu Jan 5 | atYoungstown St | L56-78 | 7-9 | .438 | - | | Beeghly Center · Youngstown, OH |
| 17 | Mon Jan 9 | vsIU Indy | W77-70 | 8-9 | .471 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Thu Jan 12 | atOakland | L65-69 | 8-10 | .444 | - | | Athletics Center O'rena · Rochester, MI |
| 19 | Sat Jan 14 | atDetroit Mercy | L75-87 | 8-11 | .421 | - | | Calihan Hall · Detroit, MI |
| 20 | Thu Jan 19 | atMilwaukee | L69-77 | 8-12 | .400 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Sat Jan 21 | atGreen Bay | W72-38 | 9-12 | .429 | - | | Resch Center · Ashwaubenon, WI |
| 22 | Fri Jan 27 | vsDetroit Mercy | W85-77 | 10-12 | .455 | - | | UPMC Events Center · Moon Township, PA |
| 23 | Sun Jan 29 | vsOakland | W68-63 | 11-12 | .478 | - | | UPMC Events Center · Moon Township, PA |
| 24 | Thu Feb 2 | vsN Kentucky | L52-65 | 11-13 | .458 | - | | UPMC Events Center · Moon Township, PA |
| 25 | Sat Feb 4 | vsWright St | L67-82 | 11-14 | .440 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Fri Feb 10 | atCleveland St | L55-57 | 11-15 | .423 | - | | Wolstein Center · Cleveland, OH |
| 27 | Sun Feb 12 | atPurdue FW | W71-64 | 12-15 | .444 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 28 | Thu Feb 16 | vsGreen Bay | W71-56 | 13-15 | .464 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sat Feb 18 | vsMilwaukee | W80-60 | 14-15 | .483 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Tue Feb 21 | vsYoungstown St | W83-64 | 15-15 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 31 | Thu Feb 23 | atIU Indy | L75-81 | 15-16 | .484 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Tue Feb 28 | vsIU Indy | W67-64 | 16-16 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 33 | Thu Mar 2 | atCleveland St | L70-75 (OT) | 16-17 | .485 | - | | Wolstein Center · Cleveland, OH |
