| 1 | Tue Nov 4 | at Iowa | L69-101 | 0-1 | .000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Thu Nov 6 | atDrake | W81-79 (OT) | 1-1 | .500 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 3 | Mon Nov 10 | vsTBD | W93-47 | 2-1 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 4 | Thu Nov 13 | vsTBD | W81-57 | 3-1 | .750 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 5 | Thu Nov 20 | atSt Bonaventure | L61-75 | 3-2 | .600 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 6 | Sun Nov 23 | atMonmouth | L70-71 (OT) | 3-3 | .500 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 7 | Wed Nov 26 | vsUIC | W88-74 | 4-3 | .571 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 8 | Fri Nov 28 | vsSouthern Utah | W61-54 | 5-3 | .625 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 9 | Sun Nov 30 | vsStetson | W80-62 | 6-3 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 10 | Thu Dec 4 | atGreen Bay | W80-78 | 7-3 | .700 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 11 | Sat Dec 6 | atMilwaukee | L72-74 | 7-4 | .636 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Sat Dec 13 | vsToledo | W75-70 | 8-4 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 13 | Wed Dec 17 | vsYoungstown St | W80-77 (OT) | 9-4 | .692 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 14 | Sat Dec 20 | atSt Francis PA | W79-70 | 10-4 | .714 | - | | DeGol Arena · Loretto, PA |
| 15 | Mon Dec 29 | vsN Kentucky | L77-79 | 10-5 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 16 | Fri Jan 2 | atDetroit Mercy | W85-77 | 11-5 | .688 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 17 | Sun Jan 4 | atOakland | L73-96 | 11-6 | .647 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsPurdue FW | L74-79 | 11-7 | .611 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 19 | Thu Jan 15 | atIU Indy | L93-96 (OT) | 11-8 | .579 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Sat Jan 17 | atN Kentucky | W92-89 (OT) | 12-8 | .600 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 21 | Thu Jan 22 | vsMilwaukee | W88-76 | 13-8 | .619 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 24 | vsGreen Bay | L67-71 | 13-9 | .591 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 23 | Wed Jan 28 | vsIU Indy | W74-58 | 14-9 | .609 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 24 | Sat Jan 31 | atPurdue FW | L71-83 | 14-10 | .583 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Wed Feb 4 | vsWright St | W72-66 | 15-10 | .600 | - | ESPNU | UPMC Events Center · Moon Township, PA |
| 26 | Sat Feb 7 | atYoungstown St | W72-66 | 16-10 | .615 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 27 | Thu Feb 12 | atCleveland St | W85-68 | 17-10 | .630 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 28 | Sun Feb 15 | vsOakland | W93-69 | 18-10 | .643 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 29 | Sun Feb 22 | atWright St | W81-68 | 19-10 | .655 | - | ESPNU | Nutter Center · Dayton, OH |
| 30 | Wed Feb 25 | vsDetroit Mercy | W73-62 | 20-10 | .667 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 31 | Sat Feb 28 | vsCleveland St | W83-64 | 21-10 | .677 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
