| 10 | Thu Dec 4 | at Green Bay | 7:00 PM | 4-5 | .444 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 11 | Sat Dec 6 | atMilwaukee | 8:00 PM | 3-5 | .375 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Sat Dec 13 | vsToledo | 1:00 PM | 5-3 | .625 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 13 | Wed Dec 17 | vsYoungstown St | 7:00 PM | 5-4 | .556 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 14 | Sat Dec 20 | atSt Francis PA | 1:00 PM | 2-7 | .222 | - | | DeGol Arena · Loretto, PA |
| 15 | Mon Dec 29 | vsN Kentucky | 7:00 PM | 7-2 | .778 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 16 | Fri Jan 2 | atDetroit Mercy | 7:00 PM | 3-6 | .333 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 17 | Sun Jan 4 | atOakland | 3:00 PM | 4-5 | .444 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsPurdue FW | 2:00 PM | 4-6 | .400 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 19 | Thu Jan 15 | atIU Indy | 6:30 PM | 3-7 | .300 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Sat Jan 17 | atN Kentucky | 7:00 PM | 7-2 | .778 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 21 | Thu Jan 22 | vsMilwaukee | 7:00 PM | 3-5 | .375 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 24 | vsGreen Bay | 2:00 PM | 4-5 | .444 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 23 | Wed Jan 28 | vsIU Indy | 7:00 PM | 3-7 | .300 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 24 | Sat Jan 31 | atPurdue FW | 1:00 PM | 4-6 | .400 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Wed Feb 4 | vsWright St | 7:00 PM | 4-5 | .444 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 26 | Sat Feb 7 | atYoungstown St | 4:30 PM | 5-4 | .556 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 27 | Thu Feb 12 | atCleveland St | 7:00 PM | 3-7 | .300 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 28 | Sun Feb 15 | vsOakland | 2:00 PM | 4-5 | .444 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 29 | Sun Feb 22 | atWright St | 2:00 PM | 4-5 | .444 | - | ESPN+ | Nutter Center · Dayton, OH |
| 30 | Wed Feb 25 | vsDetroit Mercy | 7:00 PM | 3-6 | .333 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 31 | Sat Feb 28 | vsCleveland St | 1:00 PM | 3-7 | .300 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
