| 1 | Tue Nov 4 | at Iowa | TBD | 17-16 | .515 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Thu Nov 6 | atDrake | TBD | 31-4 | .886 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 3 | Mon Nov 10 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 4 | Thu Nov 13 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 5 | Thu Nov 20 | atSt Bonaventure | TBD | 22-12 | .647 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 6 | Sun Nov 23 | atMonmouth | TBD | 13-20 | .394 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 7 | Wed Nov 26 | vsUIC | 2:00 PM | 17-14 | .548 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 8 | Fri Nov 28 | vsSouthern Utah | 2:00 PM | 12-19 | .387 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 9 | Sun Nov 30 | vsStetson | 2:00 PM | 8-24 | .250 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 10 | Thu Dec 4 | atGreen Bay | 7:00 PM | 4-28 | .125 | - | | Resch Center · Ashwaubenon, WI |
| 11 | Sat Dec 6 | atMilwaukee | TBD | 21-11 | .656 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Sat Dec 13 | vsToledo | 1:00 PM | 18-15 | .545 | - | | UPMC Events Center · Moon Township, PA |
| 13 | Wed Dec 17 | vsYoungstown St | 7:00 PM | 21-13 | .618 | - | | UPMC Events Center · Moon Township, PA |
| 14 | Sat Dec 20 | atSt Francis PA | TBD | 16-18 | .471 | - | | DeGol Arena · Loretto, PA |
| 15 | Mon Dec 29 | vsN Kentucky | 7:00 PM | 17-16 | .515 | - | | UPMC Events Center · Moon Township, PA |
| 16 | Fri Jan 2 | atDetroit Mercy | 7:00 PM | 8-24 | .250 | - | | Calihan Hall · Detroit, MI |
| 17 | Sun Jan 4 | atOakland | 3:00 PM | 16-18 | .471 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsPurdue FW | 1:00 PM | 19-13 | .594 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Thu Jan 15 | atIU Indy | 6:30 PM | 10-22 | .313 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Sat Jan 17 | atN Kentucky | 7:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 21 | Thu Jan 22 | vsMilwaukee | 7:00 PM | 21-11 | .656 | - | | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 24 | vsGreen Bay | 2:00 PM | 4-28 | .125 | - | | UPMC Events Center · Moon Township, PA |
| 23 | Wed Jan 28 | vsIU Indy | 7:00 PM | 10-22 | .313 | - | | UPMC Events Center · Moon Township, PA |
| 24 | Sat Jan 31 | atPurdue FW | 1:00 PM | 19-13 | .594 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Wed Feb 4 | vsWright St | 7:00 PM | 15-18 | .455 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Sat Feb 7 | atYoungstown St | 4:30 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 27 | Thu Feb 12 | atCleveland St | 7:00 PM | 23-13 | .639 | - | | Wolstein Center · Cleveland, OH |
| 28 | Sun Feb 15 | vsOakland | 2:00 PM | 16-18 | .471 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sun Feb 22 | atWright St | TBD | 15-18 | .455 | - | | Nutter Center · Dayton, OH |
| 30 | Wed Feb 25 | vsDetroit Mercy | 7:00 PM | 8-24 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 31 | Sat Feb 28 | vsCleveland St | 1:00 PM | 23-13 | .639 | - | | UPMC Events Center · Moon Township, PA |
