| 1 | Wed Nov 10 | at UCF | L59-69 | 0-1 | .000 | - | | Addition Financial Arena · Orlando, FL |
| 2 | Fri Nov 12 | atKentucky | L60-100 | 0-2 | .000 | - | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Mon Nov 15 | atOhio | L71-85 | 0-3 | .000 | - | | Convocation Center (OH) · Athens, OH |
| 4 | Fri Nov 19 | vsMount St Mary | L70-74 (OT) | 0-4 | .000 | - | | UPMC Events Center · Moon Township, PA |
| 5 | Sat Nov 27 | atDavidson | L70-88 | 0-5 | .000 | - | | John M. Belk Arena · Davidson, NC |
| 6 | Thu Dec 2 | atGreen Bay | L58-70 | 0-6 | .000 | - | | Resch Center · Ashwaubenon, WI |
| 7 | Sat Dec 4 | atMilwaukee | L69-77 | 0-7 | .000 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 8 | Wed Dec 8 | vsTBD | W99-51 | 1-7 | .125 | - | | UPMC Events Center · Moon Township, PA |
| 9 | Sat Dec 11 | vsFGCU | L74-85 | 1-8 | .111 | - | | UPMC Events Center · Moon Township, PA |
| 10 | Sun Dec 19 | atBowling Green | L74-100 | 1-9 | .100 | - | | Stroh Center · Bowling Green, OH |
| 11 | Wed Dec 22 | atSt Francis PA | W75-67 | 2-9 | .182 | - | | DeGol Arena · Loretto, PA |
| 12 | Thu Dec 30 | atOakland | L61-79 | 2-10 | .167 | - | | Athletics Center O'rena · Rochester, MI |
| 14 | Wed Jan 5 | vsYoungstown St | L60-64 | 2-11 | .154 | - | | UPMC Events Center · Moon Township, PA |
| 15 | Fri Jan 7 | vsCleveland St | L77-78 | 2-12 | .143 | - | | UPMC Events Center · Moon Township, PA |
| 16 | Sun Jan 9 | vsPurdue FW | L70-76 | 2-13 | .133 | - | | UPMC Events Center · Moon Township, PA |
| 17 | Thu Jan 13 | vsWright St | L73-75 | 2-14 | .125 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Sat Jan 15 | vsN Kentucky | W74-64 | 3-14 | .176 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Fri Jan 21 | atPurdue FW | L62-86 | 3-15 | .167 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Sun Jan 23 | atCleveland St | L68-75 | 3-16 | .158 | - | | Wolstein Center · Cleveland, OH |
| 21 | Thu Jan 27 | vsMilwaukee | W77-53 | 4-16 | .200 | - | | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 29 | vsGreen Bay | W62-60 | 5-16 | .238 | - | | UPMC Events Center · Moon Township, PA |
| 23 | Thu Feb 3 | atUIC | L75-80 | 5-17 | .227 | - | | Credit Union 1 Arena · Chicago, IL |
| 24 | Sat Feb 5 | atIU Indy | W66-49 | 6-17 | .261 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 25 | Wed Feb 9 | vsDetroit Mercy | L62-79 | 6-18 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Fri Feb 11 | vsOakland | L68-71 | 6-19 | .240 | - | | UPMC Events Center · Moon Township, PA |
| 27 | Sun Feb 13 | atYoungstown St | W73-68 | 7-19 | .269 | - | | Beeghly Center · Youngstown, OH |
| 28 | Thu Feb 17 | vsIU Indy | L56-66 | 7-20 | .259 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sat Feb 19 | vsUIC | L88-96 (OT) | 7-21 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Thu Feb 24 | atN Kentucky | L64-78 | 7-22 | .241 | - | | Truist Arena · Highland Heights, KY |
| 31 | Sat Feb 26 | atWright St | L61-71 | 7-23 | .233 | - | | Nutter Center · Dayton, OH |
| 32 | Tue Mar 1 | atYoungstown St | W77-73 | 8-23 | .258 | - | | Beeghly Center · Youngstown, OH |
| 33 | Thu Mar 3 | atCleveland St | L67-83 | 8-24 | .250 | - | | Wolstein Center · Cleveland, OH |
