| 1 | Thu Nov 7 | at Marshall | L60-67 | 0-1 | .000 | - | | Cam Henderson Center · Huntington, WV |
| 2 | Sat Nov 9 | atNotre Dame | L57-92 | 0-2 | .000 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 12 | vsPitt | L57-71 | 0-3 | .000 | - | ESPNU | UPMC Events Center · Moon Township, PA |
| 4 | Fri Nov 15 | vsHoward | W85-65 | 1-3 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 5 | Sat Nov 16 | atToledo | L56-70 | 1-4 | .200 | - | | Savage Arena · Toledo, OH |
| 6 | Thu Nov 21 | atUIC | L62-72 | 1-5 | .167 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Sat Nov 23 | atMarquette | L62-66 | 1-6 | .143 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 8 | Wed Nov 27 | vsTBD | W102-62 | 2-6 | .250 | - | | UPMC Events Center · Moon Township, PA |
| 9 | Sat Nov 30 | atCleveland St | L59-70 | 2-7 | .222 | - | | Wolstein Center · Cleveland, OH |
| 10 | Wed Dec 4 | atYoungstown St | L70-81 | 2-8 | .200 | - | | Beeghly Center · Youngstown, OH |
| 11 | Sat Dec 7 | atFGCU | W64-59 | 3-8 | .273 | - | | Alico Arena · Fort Myers, FL |
| 12 | Tue Dec 17 | vsC Michigan | W83-79 | 4-8 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 13 | Sat Dec 21 | atUNLV | L69-81 | 4-9 | .308 | - | | Thomas & Mack Center · Las Vegas, NV |
| 14 | Thu Jan 2 | atC Connecticut | W89-78 | 5-9 | .357 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 15 | Sat Jan 4 | atMerrimack | W69-58 | 6-9 | .400 | - | | placeholder · sf, ca |
| 16 | Thu Jan 9 | vsSt Francis BK | W78-52 | 7-9 | .438 | - | | UPMC Events Center · Moon Township, PA |
| 17 | Sat Jan 11 | vsWagner | W94-62 | 8-9 | .471 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Sat Jan 18 | vsMerrimack | L49-53 | 8-10 | .444 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Mon Jan 20 | vsSacred Heart | W67-55 | 9-10 | .474 | - | CBS | UPMC Events Center · Moon Township, PA |
| 20 | Thu Jan 23 | atSt Francis BK | L57-78 | 9-11 | .450 | - | | Pope Physical Education Center · Brooklyn, NY |
| 21 | Sat Jan 25 | atLong Island | W71-66 | 10-11 | .476 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 22 | Thu Jan 30 | vsBryant | W64-54 | 11-11 | .500 | - | | UPMC Events Center · Moon Township, PA |
| 23 | Sat Feb 1 | vsC Connecticut | W64-57 | 12-11 | .522 | - | | UPMC Events Center · Moon Township, PA |
| 24 | Thu Feb 6 | atWagner | W67-62 | 13-11 | .542 | - | | Spiro Sports Center · Staten Island, NY |
| 25 | Sat Feb 8 | atSacred Heart | W61-58 | 14-11 | .560 | - | | William H. Pitt Center · Fairfield, CT |
| 26 | Thu Feb 13 | atMount St Mary | W77-60 | 15-11 | .577 | - | | Knott Arena · Emmitsburg, MD |
| 27 | Sat Feb 15 | vsFairleigh | L71-72 | 15-12 | .556 | - | | UPMC Events Center · Moon Township, PA |
| 28 | Tue Feb 18 | atSt Francis PA | L71-86 | 15-13 | .536 | - | | DeGol Arena · Loretto, PA |
| 29 | Fri Feb 21 | vsMount St Mary | W68-60 | 16-13 | .552 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Sun Feb 23 | atFairleigh | L70-75 | 16-14 | .533 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 31 | Sat Feb 29 | vsSt Francis PA | W78-68 | 17-14 | .548 | - | | UPMC Events Center · Moon Township, PA |
| 32 | Wed Mar 4 | vsSt Francis BK | W59-58 | 18-14 | .563 | - | | UPMC Events Center · Moon Township, PA |
| 33 | Sat Mar 7 | vsLong Island | W86-66 | 19-14 | .576 | - | | UPMC Events Center · Moon Township, PA |
| 34 | Tue Mar 10 | vsSt Francis PA | W77-67 | 20-14 | .588 | - | ESPN2 | UPMC Events Center · Moon Township, PA |
