| 1 | Mon Nov 4 | vs TBD | W91-43 | 1-0 | 1.000 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 8 | vs Yale | W91-79 | 2-0 | 1.000 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 3 | Tue Nov 12 | at Northwestern | L74-83 | 2-1 | .667 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 4 | Sat Nov 16 | vsTBD | W117-59 | 3-1 | .750 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 5 | Thu Nov 21 | vs JMU | L81-99 | 3-2 | .600 | - | | Credit Union 1 Arena · Chicago, IL |
| 6 | Fri Nov 22 | vs La Salle | W96-83 | 4-2 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Sat Nov 23 | vs E Carolina | L55-72 | 4-3 | .571 | - | | Credit Union 1 Arena · Chicago, IL |
| 8 | Wed Dec 4 | vs Northern Iowa | L56-83 | 4-4 | .500 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 9 | Sun Dec 8 | vs Dartmouth | W69-68 (OT) | 5-4 | .556 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 10 | Sun Dec 15 | at Little Rock | W77-69 (OT) | 6-4 | .600 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 11 | Fri Dec 20 | at Seattle U | W79-68 | 7-4 | .636 | - | ESPN+ | Redhawk Center · Seattle, WA |
| 12 | Sun Dec 29 | at Illinois St | W73-67 | 8-4 | .667 | - | ESPN+ | Redbird Arena · Normal, IL |
| 13 | Wed Jan 1 | vs Drake | W74-70 | 9-4 | .692 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 14 | Sat Jan 4 | at Belmont | L87-92 | 9-5 | .643 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 15 | Tue Jan 7 | at Missouri St | W80-63 | 10-5 | .667 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 16 | Sat Jan 11 | vs Bradley | L60-61 | 10-6 | .625 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 17 | Wed Jan 15 | vs Murray St | W97-93 (2OT) | 11-6 | .647 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 18 | Sat Jan 18 | at Valparaiso | W81-74 | 12-6 | .667 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 19 | Wed Jan 22 | at Evansville | W78-67 | 13-6 | .684 | - | ESPN+ | Ford Center · Evansville, IN |
| 20 | Sat Jan 25 | vs S Illinois | L85-89 | 13-7 | .650 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 21 | Wed Jan 29 | atBradley | W93-70 | 14-7 | .667 | - | ESPN+ | Carver Arena · Peoria, IL |
| 22 | Sat Feb 1 | vs Indiana St | L83-88 | 14-8 | .636 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 23 | Wed Feb 5 | vsIllinois St | L79-81 | 14-9 | .609 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 24 | Sat Feb 8 | atS Illinois | L67-79 | 14-10 | .583 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 25 | Tue Feb 11 | atMurray St | L53-63 | 14-11 | .560 | - | ESPN+ | CFSB Center · Murray, KY |
| 26 | Sun Feb 16 | vsMissouri St | W63-58 | 15-11 | .577 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 27 | Wed Feb 19 | atDrake | L57-74 | 15-12 | .556 | - | ESPN+ | The Knapp Center · Des Moines, IA |
