| 1 | Mon Nov 3 | vs Detroit Mercy | W91-71 | 1-0 | 1.000 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 7 | atOregon St | L73-76 | 1-1 | .500 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 3 | Tue Nov 11 | vsTBD | W98-55 | 2-1 | .667 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 4 | Sat Nov 15 | atChicago St | W67-63 | 3-1 | .750 | - | | Jones Convocation Center · Chicago, IL |
| 5 | Thu Nov 20 | vsHigh Point | L80-90 | 3-2 | .600 | - | | Credit Union 1 Arena · Chicago, IL |
| 6 | Sat Nov 22 | vsSo Indiana | W84-73 | 4-2 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Wed Nov 26 | atRobert Morris | L74-88 | 4-3 | .571 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 8 | Wed Dec 3 | vsAR-Pine Bluff | L62-63 | 4-4 | .500 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 9 | Sun Dec 7 | atYale | L66-80 | 4-5 | .444 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 10 | Sat Dec 13 | atBelmont | L84-87 | 4-6 | .400 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 11 | Wed Dec 17 | vsNorthern Iowa | L54-60 | 4-7 | .364 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 12 | Sun Dec 21 | atCharlotte | L76-88 (OT) | 4-8 | .333 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 13 | Mon Dec 29 | vsTBD | W102-64 | 5-8 | .385 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 14 | Thu Jan 1 | vsMurray St | L77-81 | 5-9 | .357 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 15 | Sun Jan 4 | atValparaiso | L59-66 | 5-10 | .333 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 16 | Wed Jan 7 | vsS Illinois | W70-57 | 6-10 | .375 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 17 | Sat Jan 10 | atIllinois St | W63-59 (OT) | 7-10 | .412 | - | ESPN+ | Redbird Arena · Normal, IL |
| 18 | Tue Jan 13 | atNorthern Iowa | W69-61 | 8-10 | .444 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 19 | Sat Jan 17 | vsDrake | W74-67 | 9-10 | .474 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 20 | Tue Jan 20 | vsEvansville | W76-49 | 10-10 | .500 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 21 | Sat Jan 24 | atBradley | W85-70 | 11-10 | .524 | - | ESPN+ | Carver Arena · Peoria, IL |
| 22 | Tue Jan 27 | vsIndiana St | W76-74 | 12-10 | .545 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 23 | Sat Jan 31 | atS Illinois | W68-66 | 13-10 | .565 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 24 | Tue Feb 3 | atMurray St | L74-81 | 13-11 | .542 | - | ESPN+ | CFSB Center · Murray, KY |
| 25 | Fri Feb 6 | vsBelmont | L62-68 | 13-12 | .520 | - | ESPNU | Credit Union 1 Arena · Chicago, IL |
| 26 | Thu Feb 12 | atDrake | W80-70 | 14-12 | .538 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 27 | Sun Feb 15 | vsIllinois St | W83-56 | 15-12 | .556 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 28 | Wed Feb 18 | atEvansville | W84-46 | 16-12 | .571 | - | ESPN+ | Ford Center · Evansville, IN |
| 29 | Sat Feb 21 | vsValparaiso | L67-71 | 16-13 | .552 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 30 | Tue Feb 24 | vsBradley | W93-86 (2OT) | 17-13 | .567 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 31 | Sun Mar 1 | atIndiana St | L63-79 | 17-14 | .548 | - | ESPN+ | Hulman Center · Terre Haute, IN |
