| 1 | Mon Nov 7 | vs TBD | W82-48 | 1-0 | 1.000 | - | | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 11 | vs Loyola Chicago | L63-70 | 1-1 | .500 | - | | Credit Union 1 Arena · Chicago, IL |
| 3 | Mon Nov 14 | vs J'Ville St | W67-60 | 2-1 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 4 | Sat Nov 19 | at Fordham | L65-79 | 2-2 | .500 | - | | Rose Hill Gymnasium · Bronx, NY |
| 5 | Mon Nov 21 | at Stonehill | W77-71 | 3-2 | .600 | - | | placeholder · sf, ca |
| 6 | Tue Nov 22 | vs Holy Cross | W89-66 | 4-2 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Sat Nov 26 | at Green Bay | W78-64 | 5-2 | .714 | - | | Resch Center · Ashwaubenon, WI |
| 8 | Wed Nov 30 | vs Missouri St | L51-66 | 5-3 | .625 | - | | Credit Union 1 Arena · Chicago, IL |
| 9 | Sat Dec 3 | at Drake | L64-77 | 5-4 | .556 | - | | The Knapp Center · Des Moines, IA |
| 10 | Sat Dec 10 | at W Michigan | W62-56 | 6-4 | .600 | - | | University Arena (MI) · Kalamazoo, MI |
| 11 | Tue Dec 13 | vs Prairie View | W70-61 | 7-4 | .636 | - | | Credit Union 1 Arena · Chicago, IL |
| 12 | Sun Dec 18 | vs Northeastern | W81-73 | 8-4 | .667 | - | | Credit Union 1 Arena · Chicago, IL |
| 13 | Tue Dec 20 | at Northwestern | L54-92 | 8-5 | .615 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 14 | Wed Dec 28 | vs Illinois St | W55-51 | 9-5 | .643 | - | | Credit Union 1 Arena · Chicago, IL |
| 15 | Sat Dec 31 | at Bradley | L45-79 | 9-6 | .600 | - | | Carver Arena · Peoria, IL |
| 16 | Wed Jan 4 | vs Belmont | L71-77 | 9-7 | .563 | - | | Credit Union 1 Arena · Chicago, IL |
| 17 | Sat Jan 7 | at Indiana St | L60-80 | 9-8 | .529 | - | | Hulman Center · Terre Haute, IN |
| 18 | Tue Jan 10 | vsDrake | L71-76 (OT) | 9-9 | .500 | - | | Credit Union 1 Arena · Chicago, IL |
| 19 | Sat Jan 14 | at Murray St | L64-81 | 9-10 | .474 | - | | CFSB Center · Murray, KY |
| 20 | Tue Jan 17 | at Valparaiso | L66-76 | 9-11 | .450 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 21 | Sat Jan 21 | vs Northern Iowa | L72-78 | 9-12 | .429 | - | | Credit Union 1 Arena · Chicago, IL |
| 22 | Tue Jan 24 | atMissouri St | L59-63 | 9-13 | .409 | - | | Great Southern Bank Arena · Springfield, MO |
| 23 | Sun Jan 29 | vsBradley | L76-83 | 9-14 | .391 | - | | Credit Union 1 Arena · Chicago, IL |
| 24 | Wed Feb 1 | atIllinois St | L62-68 (OT) | 9-15 | .375 | - | | Redbird Arena · Normal, IL |
| 25 | Sat Feb 4 | vs Evansville | W70-61 | 10-15 | .400 | - | | Credit Union 1 Arena · Chicago, IL |
| 26 | Wed Feb 8 | at S Illinois | L66-68 | 10-16 | .385 | - | | Banterra Center · Carbondale, IL |
| 27 | Sat Feb 11 | atBelmont | L71-98 | 10-17 | .370 | - | | Curb Event Center Arena · Nashville, TN |
| 28 | Wed Feb 15 | vsIndiana St | L60-79 | 10-18 | .357 | - | | Credit Union 1 Arena · Chicago, IL |
| 29 | Sun Feb 19 | vsValparaiso | W74-73 | 11-18 | .379 | - | | Credit Union 1 Arena · Chicago, IL |
| 30 | Wed Feb 22 | atEvansville | W82-76 | 12-18 | .400 | - | | Ford Center · Evansville, IN |
| 31 | Sun Feb 26 | vsS Illinois | L65-68 | 12-19 | .387 | - | | Credit Union 1 Arena · Chicago, IL |
| 32 | Thu Mar 2 | atMissouri St | L57-74 | 12-20 | .375 | - | | Great Southern Bank Arena · Springfield, MO |
