| 1 | Tue Nov 5 | vs TBD | W75-72 | 1-0 | 1.000 | - | | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 8 | at Memphis | L46-92 | 1-1 | .500 | - | ESPNU | FedExForum · Memphis, TN |
| 3 | Wed Nov 13 | vs Ball State | L48-67 | 1-2 | .333 | - | | Credit Union 1 Arena · Chicago, IL |
| 4 | Sat Nov 16 | at Bradley | L56-65 | 1-3 | .250 | - | | Carver Arena · Peoria, IL |
| 5 | Thu Nov 21 | vs Robert Morris | W72-62 | 2-3 | .400 | - | | Credit Union 1 Arena · Chicago, IL |
| 6 | Sat Nov 23 | vs Mercer | L68-72 | 2-4 | .333 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Tue Nov 26 | vs Canisius | L64-94 | 2-5 | .286 | - | | Credit Union 1 Arena · Chicago, IL |
| 8 | Sun Dec 1 | at FAU | L70-71 | 2-6 | .250 | - | | FAU Arena · Boca Raton, FL |
| 9 | Mon Dec 2 | vs San Diego | W89-83 | 3-6 | .333 | - | | Credit Union 1 Arena · Chicago, IL |
| 10 | Sat Dec 7 | vs Purdue FW | W62-49 | 4-6 | .400 | - | | Credit Union 1 Arena · Chicago, IL |
| 11 | Sat Dec 14 | at DePaul | L65-86 | 4-7 | .364 | - | FS1 | Wintrust Arena · Chicago, IL |
| 12 | Wed Dec 18 | at Illinois St | L66-67 | 4-8 | .333 | - | | Redbird Arena · Normal, IL |
| 13 | Fri Dec 20 | vs UC Irvine | W76-67 | 5-8 | .385 | - | | Credit Union 1 Arena · Chicago, IL |
| 14 | Sat Dec 28 | vs Cleveland St | W71-66 | 6-8 | .429 | - | | Credit Union 1 Arena · Chicago, IL |
| 15 | Mon Dec 30 | vs Youngstown St | L64-70 | 6-9 | .400 | - | | Credit Union 1 Arena · Chicago, IL |
| 16 | Fri Jan 3 | at Green Bay | L71-85 | 6-10 | .375 | - | | Resch Center · Ashwaubenon, WI |
| 17 | Sun Jan 5 | at Milwaukee | L62-64 | 6-11 | .353 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 18 | Fri Jan 10 | vs N Kentucky | L52-68 | 6-12 | .333 | - | ESPN2 | Credit Union 1 Arena · Chicago, IL |
| 19 | Sun Jan 12 | vs Wright St | W76-72 | 7-12 | .368 | - | | Credit Union 1 Arena · Chicago, IL |
| 20 | Sat Jan 18 | at IU Indy | W75-66 | 8-12 | .400 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Thu Jan 23 | at Oakland | W80-50 | 9-12 | .429 | - | | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 25 | at Detroit Mercy | L69-70 | 9-13 | .409 | - | | Calihan Hall · Detroit, MI |
| 23 | Thu Jan 30 | atYoungstown St | W90-83 (OT) | 10-13 | .435 | - | | Beeghly Center · Youngstown, OH |
| 24 | Sat Feb 1 | atCleveland St | W64-62 | 11-13 | .458 | - | | Wolstein Center · Cleveland, OH |
| 25 | Thu Feb 6 | vsMilwaukee | L57-74 | 11-14 | .440 | - | | Credit Union 1 Arena · Chicago, IL |
| 26 | Sat Feb 8 | vsGreen Bay | W71-58 | 12-14 | .462 | - | | Credit Union 1 Arena · Chicago, IL |
| 27 | Fri Feb 14 | atWright St | L58-75 | 12-15 | .444 | - | ESPN2 | Nutter Center · Dayton, OH |
| 28 | Sun Feb 16 | atN Kentucky | W73-43 | 13-15 | .464 | - | | Truist Arena · Highland Heights, KY |
| 29 | Sat Feb 22 | vsIU Indy | W77-72 | 14-15 | .483 | - | | Credit Union 1 Arena · Chicago, IL |
| 30 | Thu Feb 27 | vsDetroit Mercy | W84-67 | 15-15 | .500 | - | | Credit Union 1 Arena · Chicago, IL |
| 31 | Sat Feb 29 | vsOakland | L66-68 | 15-16 | .484 | - | | Credit Union 1 Arena · Chicago, IL |
| 32 | Tue Mar 3 | vsIU Indy | W93-59 | 16-16 | .500 | - | | Credit Union 1 Arena · Chicago, IL |
| 33 | Thu Mar 5 | vsYoungstown St | W67-61 | 17-16 | .515 | - | | Credit Union 1 Arena · Chicago, IL |
| 34 | Mon Mar 9 | atWright St | W73-56 | 18-16 | .529 | - | ESPNU | Nutter Center · Dayton, OH |
| 35 | Tue Mar 10 | atN Kentucky | L62-71 | 18-17 | .514 | - | ESPN | Truist Arena · Highland Heights, KY |
