| 1 | Mon Nov 4 | vs TBD | W118-62 | 1-0 | 1.000 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 2 | Thu Nov 7 | at Northern Iowa | L68-87 | 1-1 | .500 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 3 | Wed Nov 13 | at Longwood | L62-76 | 1-2 | .333 | - | ESPN+ | Willett Hall · Farmville, VA |
| 4 | Tue Nov 19 | at Duquesne | W80-74 | 2-2 | .500 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 5 | Fri Nov 22 | vs Portland St | W91-74 | 3-2 | .600 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 6 | Sat Nov 23 | vs Wofford | W76-74 | 4-2 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 7 | Sun Nov 24 | vs St Thomas (MN) | W69-65 | 5-2 | .714 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 8 | Wed Nov 27 | at UCF | L76-84 | 5-3 | .625 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 9 | Sat Nov 30 | at Southern Miss | L65-66 | 5-4 | .556 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 10 | Thu Dec 5 | vs Cleveland St | W79-67 | 6-4 | .600 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 11 | Wed Dec 11 | at Green Bay | W88-67 | 7-4 | .636 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 12 | Sun Dec 15 | vs Akron | W100-81 | 8-4 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 13 | Sun Dec 22 | vsTBD | W92-57 | 9-4 | .692 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 14 | Sun Dec 29 | vs IU Indy | W88-81 | 10-4 | .714 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 15 | Thu Jan 2 | at Oakland | L49-65 | 10-5 | .667 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 16 | Sat Jan 4 | at Detroit Mercy | W64-56 | 11-5 | .688 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 17 | Wed Jan 8 | at Purdue FW | L73-78 | 11-6 | .647 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Sat Jan 11 | vsGreen Bay | W70-59 | 12-6 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 19 | Fri Jan 17 | vs Youngstown St | W79-64 | 13-6 | .684 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sun Jan 19 | vs Robert Morris | L79-81 | 13-7 | .650 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Wed Jan 22 | at Wright St | W95-79 | 14-7 | .667 | - | ESPN+ | Nutter Center · Dayton, OH |
| 22 | Fri Jan 24 | at N Kentucky | W79-59 | 15-7 | .682 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 23 | Sun Feb 2 | vsPurdue FW | L79-81 | 15-8 | .652 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Wed Feb 5 | atIU Indy | W84-80 (OT) | 16-8 | .667 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 25 | Sat Feb 8 | atCleveland St | L60-77 | 16-9 | .640 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 26 | Fri Feb 14 | vsWright St | W88-80 (OT) | 17-9 | .654 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Sun Feb 16 | vsN Kentucky | W92-70 | 18-9 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
