| 1 | Mon Nov 6 | vs TBD | W91-73 | 1-0 | 1.000 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 2 | Sat Nov 11 | at Providence | L69-79 | 1-1 | .500 | - | FS2 | Amica Mutual Pavilion · Providence, RI |
| 3 | Tue Nov 14 | at #25Colorado | L79-106 | 1-2 | .333 | - | PACN | CU Events Center · Boulder, CO |
| 4 | Fri Nov 17 | vsTBD | W85-56 | 2-2 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 5 | Mon Nov 20 | at Stetson | L67-85 | 2-3 | .400 | - | | Edmunds Center · Deland, FL |
| 6 | Tue Nov 21 | vs Siena | W61-59 | 3-3 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 7 | Sat Nov 25 | vs Southern Miss | L84-90 | 3-4 | .429 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 8 | Sat Dec 2 | at Green Bay | L58-70 | 3-5 | .375 | - | | Resch Center · Ashwaubenon, WI |
| 9 | Wed Dec 6 | at St Thomas (MN) | L71-75 | 3-6 | .333 | - | | Schoenecker Arena · Saint Paul, MN |
| 10 | Sat Dec 9 | at UC Davis | W81-79 | 4-6 | .400 | - | | University Credit Union Center · Davis, CA |
| 11 | Wed Dec 13 | vs Longwood | L67-80 | 4-7 | .364 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Fri Dec 22 | vs Chattanooga | W85-83 (OT) | 5-7 | .417 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 13 | Fri Dec 29 | vs Robert Morris | W78-75 | 6-7 | .462 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 14 | Sun Dec 31 | vs Wright St | W91-83 | 7-7 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 15 | Thu Jan 4 | at Oakland | L95-100 | 7-8 | .467 | - | | Athletics Center O'rena · Rochester, MI |
| 16 | Sat Jan 6 | at Detroit Mercy | W84-61 | 8-8 | .500 | - | | Calihan Hall · Detroit, MI |
| 17 | Fri Jan 12 | vs Cleveland St | W88-80 | 9-8 | .529 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 18 | Thu Jan 18 | at N Kentucky | L72-90 | 9-9 | .500 | - | | Truist Arena · Highland Heights, KY |
| 19 | Sat Jan 20 | atWright St | L81-95 | 9-10 | .474 | - | | Nutter Center · Dayton, OH |
| 20 | Thu Jan 25 | vsDetroit Mercy | W87-71 | 10-10 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Sat Jan 27 | vsOakland | L87-91 (2OT) | 10-11 | .476 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 22 | Thu Feb 1 | at Purdue FW | W68-65 | 11-11 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 23 | Sun Feb 4 | vs IU Indy | W87-67 | 12-11 | .522 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Thu Feb 8 | at Youngstown St | L85-97 (OT) | 12-12 | .500 | - | | Beeghly Center · Youngstown, OH |
| 25 | Sat Feb 10 | atRobert Morris | L60-71 | 12-13 | .480 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Wed Feb 14 | atCleveland St | W71-68 | 13-13 | .500 | - | | Wolstein Center · Cleveland, OH |
| 27 | Sat Feb 17 | vsN Kentucky | W73-72 | 14-13 | .519 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Fri Feb 23 | vsYoungstown St | L80-84 (OT) | 14-14 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 29 | Sun Feb 25 | vsPurdue FW | W96-88 | 15-14 | .517 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 30 | Wed Feb 28 | atIU Indy | W75-70 | 16-14 | .533 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Mar 2 | vsGreen Bay | W90-69 | 17-14 | .548 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 32 | Tue Mar 5 | vsDetroit Mercy | W83-79 | 18-14 | .563 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 33 | Thu Mar 7 | atGreen Bay | W95-84 | 19-14 | .576 | - | | Resch Center · Ashwaubenon, WI |
| 34 | Mon Mar 11 | atN Kentucky | W82-75 | 20-14 | .588 | - | ESPN2 | Truist Arena · Highland Heights, KY |
| 35 | Tue Mar 12 | atOakland | L76-83 | 20-15 | .571 | - | ESPN | Athletics Center O'rena · Rochester, MI |
