| 1 | Tue Nov 9 | at North Dakota | W75-60 | 1-0 | 1.000 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 2 | Sat Nov 13 | vs E Kentucky | L71-77 | 1-1 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 3 | Thu Nov 18 | at #24Florida | L45-81 | 1-2 | .333 | - | | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 4 | Tue Nov 23 | at Bowling Green | L68-82 | 1-3 | .250 | - | | Stroh Center · Bowling Green, OH |
| 5 | Wed Nov 24 | at Yale | L56-69 | 1-4 | .200 | - | | John J. Lee Amphitheater · New Haven, CT |
| 6 | Sun Nov 28 | vs Alcorn St | L57-61 | 1-5 | .167 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 7 | Thu Dec 2 | vs Youngstown St | L68-70 | 1-6 | .143 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 8 | Sat Dec 4 | vs Robert Morris | W77-69 | 2-6 | .250 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 9 | Fri Dec 10 | at Colorado | L54-65 | 2-7 | .222 | - | | CU Events Center · Boulder, CO |
| 10 | Mon Dec 13 | vs Rhode Island | L58-82 | 2-8 | .200 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 11 | Thu Dec 23 | vs TBD | W74-52 | 3-8 | .273 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Thu Dec 30 | at Wright St | L75-80 | 3-9 | .250 | - | | Nutter Center · Dayton, OH |
| 13 | Sat Jan 1 | at N Kentucky | W61-55 | 4-9 | .308 | - | | Truist Arena · Highland Heights, KY |
| 14 | Wed Jan 5 | at Green Bay | W63-49 | 5-9 | .357 | - | | Resch Center · Ashwaubenon, WI |
| 15 | Fri Jan 7 | at Detroit Mercy | L60-85 | 5-10 | .333 | - | ESPN2 | Calihan Hall · Detroit, MI |
| 16 | Sun Jan 9 | at Oakland | L65-86 | 5-11 | .313 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Thu Jan 13 | vs UIC | L77-81 | 5-12 | .294 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 18 | Sat Jan 15 | vs IU Indy | W89-54 | 6-12 | .333 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 19 | Thu Jan 20 | vsOakland | W88-78 | 7-12 | .368 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sat Jan 22 | vsDetroit Mercy | L58-71 | 7-13 | .350 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Thu Jan 27 | atRobert Morris | L53-77 | 7-14 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 29 | atYoungstown St | L72-86 | 7-15 | .318 | - | | Beeghly Center · Youngstown, OH |
| 23 | Fri Feb 4 | at Purdue FW | L60-70 | 7-16 | .304 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sun Feb 6 | at Cleveland St | L71-84 | 7-17 | .292 | - | | Wolstein Center · Cleveland, OH |
| 25 | Wed Feb 9 | vsN Kentucky | L39-75 | 7-18 | .280 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 26 | Fri Feb 11 | vsWright St | W60-57 | 8-18 | .308 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Sun Feb 13 | vsGreen Bay | W54-44 | 9-18 | .333 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Fri Feb 18 | vsCleveland St | L61-78 | 9-19 | .321 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 29 | Sun Feb 20 | vsPurdue FW | L71-81 | 9-20 | .310 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 30 | Thu Feb 24 | atIU Indy | W66-54 | 10-20 | .333 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 26 | atUIC | L58-71 | 10-21 | .323 | - | | Credit Union 1 Arena · Chicago, IL |
| 32 | Tue Mar 1 | vsUIC | L69-80 | 10-22 | .313 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
