| 1 | Tue Nov 5 | vs TBD | W72-62 | 1-0 | 1.000 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 2 | Sat Nov 9 | vs W Michigan | L110-115 (3OT) | 1-1 | .500 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 3 | Tue Nov 12 | vsTBD | W103-53 | 2-1 | .667 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 4 | Fri Nov 15 | vs Kansas City | W61-52 | 3-1 | .750 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 5 | Tue Nov 19 | vs North Dakota | W79-70 | 4-1 | .800 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 6 | Fri Nov 22 | at Rice | L69-75 | 4-2 | .667 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Sat Nov 23 | at Morgan St | W62-57 | 5-2 | .714 | - | | Hill Field House · Baltimore, MD |
| 8 | Sun Nov 24 | vs G Washington | L63-66 | 5-3 | .625 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 9 | Tue Dec 3 | at Drake | L53-56 | 5-4 | .556 | - | | The Knapp Center · Des Moines, IA |
| 10 | Tue Dec 10 | at #2Kansas | L68-95 | 5-5 | .500 | - | | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Dec 14 | vs E Illinois | L68-75 | 5-6 | .455 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 12 | Sat Dec 21 | at Wisconsin | L64-83 | 5-7 | .417 | - | BTN | Kohl Center · Madison, WI |
| 13 | Sat Dec 28 | at N Kentucky | L64-74 | 5-8 | .385 | - | | Truist Arena · Highland Heights, KY |
| 14 | Mon Dec 30 | at Wright St | L70-82 | 5-9 | .357 | - | | Nutter Center · Dayton, OH |
| 15 | Fri Jan 3 | vs IU Indy | W78-74 | 6-9 | .400 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 16 | Sun Jan 5 | vs UIC | W64-62 | 7-9 | .438 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 17 | Sat Jan 11 | at Green Bay | W87-80 | 8-9 | .471 | - | | Resch Center · Ashwaubenon, WI |
| 18 | Thu Jan 16 | vs Detroit Mercy | L84-90 | 8-10 | .444 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 19 | Sat Jan 18 | vs Oakland | W73-68 | 9-10 | .474 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Thu Jan 23 | at Youngstown St | W75-73 (OT) | 10-10 | .500 | - | | Beeghly Center · Youngstown, OH |
| 21 | Sat Jan 25 | at Cleveland St | L53-70 | 10-11 | .476 | - | | Wolstein Center · Cleveland, OH |
| 22 | Fri Jan 31 | vsWright St | L61-65 | 10-12 | .455 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 23 | Sun Feb 2 | vsN Kentucky | L56-65 | 10-13 | .435 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Thu Feb 6 | atUIC | W74-57 | 11-13 | .458 | - | | Credit Union 1 Arena · Chicago, IL |
| 25 | Sat Feb 8 | atIU Indy | W80-79 (OT) | 12-13 | .480 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Sat Feb 15 | vsGreen Bay | L90-94 | 12-14 | .462 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Fri Feb 21 | atOakland | L68-75 | 12-15 | .444 | - | | Athletics Center O'rena · Rochester, MI |
| 28 | Sun Feb 23 | atDetroit Mercy | L73-79 | 12-16 | .429 | - | | Calihan Hall · Detroit, MI |
| 29 | Thu Feb 27 | vsCleveland St | L68-70 | 12-17 | .414 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 30 | Sat Feb 29 | vsYoungstown St | L69-73 | 12-18 | .400 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 31 | Tue Mar 3 | atYoungstown St | L57-63 | 12-19 | .387 | - | | Beeghly Center · Youngstown, OH |
