| 1 | Tue Nov 5 | vs FIU | W77-70 | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 2 | Sat Nov 9 | vs Florida St | L65-73 | 1-1 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 3 | Tue Nov 12 | vs UL Monroe | W66-50 | 2-1 | .667 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 4 | Sat Nov 16 | vs N'Western St | W77-75 (OT) | 3-1 | .750 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 5 | Tue Nov 19 | at Louisiana | W83-61 | 4-1 | .800 | - | ESPN+ | Cajundome · Lafayette, LA |
| 6 | Fri Nov 22 | at Hou Christian | W61-58 | 5-1 | .833 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 7 | Fri Nov 29 | at Hofstra | L63-68 (OT) | 5-2 | .714 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 8 | Sat Nov 30 | vs Arkansas St | W75-67 | 6-2 | .750 | - | | Tudor Fieldhouse · Houston, TX |
| 9 | Sun Dec 1 | at Iona | W70-66 | 7-2 | .778 | - | | Hynes Athletics Center · New Rochelle, NY |
| 10 | Sun Dec 8 | at Texas St | L66-75 | 7-3 | .700 | - | ESPN+ | Strahan Arena at the University Events Center · San Marcos, TX |
| 11 | Mon Dec 16 | vs Alcorn St | W77-75 | 8-3 | .727 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 12 | Thu Dec 19 | vs TBD | L68-69 | 8-4 | .667 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 13 | Sun Dec 22 | vs Prairie View | W64-46 | 9-4 | .692 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 14 | Wed Jan 1 | at Tulsa | W70-64 | 10-4 | .714 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sat Jan 4 | vs Charlotte | W68-55 | 11-4 | .733 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 16 | Wed Jan 8 | at North Texas | L59-81 | 11-5 | .688 | - | ESPNU | The Super Pit · Denton, TX |
| 17 | Sat Jan 11 | vs Temple | L70-73 | 11-6 | .647 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 18 | Tue Jan 14 | vs UTSA | L84-90 | 11-7 | .611 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 19 | Sun Jan 19 | at FAU | L73-75 | 11-8 | .579 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 20 | Sat Jan 25 | vs Tulane | L71-82 | 11-9 | .550 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 21 | Tue Jan 28 | at South Florida | L64-69 | 11-10 | .524 | - | ESPNU | Yuengling Center · Tampa, FL |
| 22 | Sun Feb 2 | vs #19Memphis | L83-86 | 11-11 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 23 | Wed Feb 5 | at E Carolina | W73-60 | 12-11 | .522 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Sat Feb 8 | atCharlotte | L75-78 | 12-12 | .500 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 25 | Tue Feb 11 | vsNorth Texas | L61-67 | 12-13 | .480 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 26 | Sat Feb 15 | atTulane | L78-81 | 12-14 | .462 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 27 | Wed Feb 19 | vs UAB | L89-90 | 12-15 | .444 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
Wichita St