| 1 | Tue Nov 7 | vs TBD | W101-57 | 1-0 | 1.000 | - | | Tudor Fieldhouse · Houston, TX |
| 2 | Fri Nov 10 | vs Harvard | L76-89 | 1-1 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 3 | Wed Nov 15 | at #19Texas | L64-80 | 1-2 | .333 | - | LHN | Moody Center · Austin, TX |
| 4 | Tue Nov 21 | vs Indiana St | L88-103 | 1-3 | .250 | - | | Tudor Fieldhouse · Houston, TX |
| 5 | Wed Nov 22 | at New Mexico | L56-90 | 1-4 | .200 | - | | The Pit · Albuquerque, NM |
| 6 | Fri Nov 24 | vs UC Irvine | L68-83 | 1-5 | .167 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Thu Nov 30 | vs UT Martin | W98-78 | 2-5 | .286 | - | | Tudor Fieldhouse · Houston, TX |
| 8 | Sat Dec 2 | vs Hou Christian | W65-56 | 3-5 | .375 | - | | Tudor Fieldhouse · Houston, TX |
| 9 | Wed Dec 6 | at #3Houston | L39-75 | 3-6 | .333 | - | | Fertitta Center · Houston, TX |
| 10 | Wed Dec 13 | vs Incarnate Word | W80-57 | 4-6 | .400 | - | | Tudor Fieldhouse · Houston, TX |
| 11 | Sat Dec 16 | at N'Western St | W76-51 | 5-6 | .455 | - | | Prather Coliseum · Natchitoches, LA |
| 12 | Wed Dec 20 | vs Prairie View | W82-56 | 6-6 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 13 | Fri Dec 22 | vs Louisiana | L67-84 | 6-7 | .462 | - | | Tudor Fieldhouse · Houston, TX |
| 14 | Wed Jan 3 | at Tulane | L59-84 | 6-8 | .429 | - | ESPNU | Devlin Fieldhouse · New Orleans, LA |
| 15 | Sat Jan 6 | vs UTSA | L82-89 (OT) | 6-9 | .400 | - | | Tudor Fieldhouse · Houston, TX |
| 16 | Fri Jan 12 | at South Florida | L73-81 | 6-10 | .375 | - | ESPNU | Yuengling Center · Tampa, FL |
| 17 | Tue Jan 16 | vs Charlotte | L79-81 (OT) | 6-11 | .353 | - | | Tudor Fieldhouse · Houston, TX |
| 18 | Sat Jan 20 | at Temple | W69-66 | 7-11 | .389 | - | | Liacouras Center · Philadelphia, PA |
| 19 | Wed Jan 24 | vs #22FAU | L56-69 | 7-12 | .368 | - | | Tudor Fieldhouse · Houston, TX |
| 20 | Sat Jan 27 | vs Tulsa | L83-85 | 7-13 | .350 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 21 | Wed Jan 31 | at Memphis | W74-71 | 8-13 | .381 | - | | FedExForum · Memphis, TN |
| 22 | Sat Feb 3 | atUTSA | W80-76 | 9-13 | .409 | - | | UTSA Convocation Center · San Antonio, TX |
| 23 | Wed Feb 7 | vs SMU | L69-95 | 9-14 | .391 | - | | Tudor Fieldhouse · Houston, TX |
| 24 | Sat Feb 10 | vsSouth Florida | L65-69 | 9-15 | .375 | - | | Tudor Fieldhouse · Houston, TX |
| 25 | Sat Feb 17 | atTulsa | L82-93 (OT) | 9-16 | .360 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Wed Feb 21 | at UAB | W94-71 | 10-16 | .385 | - | | Bartow Arena · Birmingham, AL |
| 27 | Sat Feb 24 | vs E Carolina | W70-52 | 11-16 | .407 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 28 | Wed Feb 28 | vsTemple | L43-65 | 11-17 | .393 | - | | Tudor Fieldhouse · Houston, TX |
| 29 | Sat Mar 2 | at Wichita St | L66-87 | 11-18 | .379 | - | | Charles Koch Arena · Wichita, KS |
| 30 | Wed Mar 6 | atCharlotte | L64-69 | 11-19 | .367 | - | | Dale F. Halton Arena · Charlotte, NC |
| 31 | Sat Mar 9 | vs North Texas | L55-71 | 11-20 | .355 | - | | Tudor Fieldhouse · Houston, TX |
| 32 | Wed Mar 13 | atWichita St | L81-88 | 11-21 | .344 | - | | Charles Koch Arena · Wichita, KS |
