| 1 | Tue Nov 4 | vs TBD | W109-38 | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 2 | Fri Nov 7 | atOregon | L63-67 | 1-1 | .500 | - | B1G+ | Matthew Knight Arena · Eugene, OR |
| 3 | Tue Nov 11 | vsSF Austin | L69-81 | 1-2 | .333 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 4 | Fri Nov 14 | vsE Texas A&M | W71-64 | 2-2 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 5 | Mon Nov 17 | at20Tennessee | L66-91 | 2-3 | .400 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 6 | Thu Nov 20 | vsTarleton | L74-90 | 2-4 | .333 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 7 | Mon Nov 24 | atKennesaw St | L84-89 (OT) | 2-5 | .286 | - | | Alico Arena · Fort Myers, FL |
| 8 | Tue Nov 25 | atFGCU | L63-78 (OT) | 2-6 | .250 | - | | Alico Arena · Fort Myers, FL |
| 9 | Wed Nov 26 | vsOral Roberts | W81-62 | 3-6 | .333 | - | | Alico Arena · Fort Myers, FL |
| 10 | Wed Dec 3 | vsTexas St | W77-72 | 4-6 | .400 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 11 | Sat Dec 13 | vsArkansas St | W77-76 | 5-6 | .455 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 12 | Wed Dec 17 | vsTBD | W94-47 | 6-6 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 13 | Sat Dec 20 | atPepperdine | L62-84 | 6-7 | .462 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 14 | Wed Dec 31 | atTulsa | L48-97 | 6-8 | .429 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sat Jan 3 | vsMemphis | L70-76 | 6-9 | .400 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 16 | Wed Jan 7 | atWichita St | W66-64 | 7-9 | .438 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 17 | Sun Jan 11 | vsCharlotte | L73-74 | 7-10 | .412 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 18 | Wed Jan 14 | atUTSA | W89-73 | 8-10 | .444 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 19 | Wed Jan 21 | vsTemple | L65-69 | 8-11 | .421 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 20 | Sat Jan 24 | vsTulsa | L81-87 | 8-12 | .400 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 21 | Wed Jan 28 | atE Carolina | W83-77 | 9-12 | .429 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Fri Jan 30 | atCharlotte | L70-80 | 9-13 | .409 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 23 | Wed Feb 4 | vsNorth Texas | W86-83 (2OT) | 10-13 | .435 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 24 | Sun Feb 8 | atUAB | L65-71 | 10-14 | .417 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 25 | Wed Feb 11 | vsFAU | W81-73 | 11-14 | .440 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 26 | Sat Feb 14 | vsE Carolina | L75-85 | 11-15 | .423 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 27 | Sun Feb 22 | atTulane | L75-81 | 11-16 | .407 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 28 | Wed Feb 25 | vsSouth Florida | L56-75 | 11-17 | .393 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 29 | Sun Mar 1 | atTemple | W80-74 | 12-17 | .414 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
