| 3 | Tue Nov 11 | vs SF Austin | 8:00 PM | 2-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 4 | Fri Nov 14 | vsE Texas A&M | 8:00 PM | 1-1 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 5 | Mon Nov 17 | at#18Tennessee | 8:30 PM | 1-0 | 1.000 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 6 | Thu Nov 20 | vsTarleton | 8:00 PM | 0-2 | .000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 7 | Mon Nov 24 | atKennesaw St | 4:30 PM | 1-0 | 1.000 | - | | Alico Arena · Fort Myers, FL |
| 8 | Tue Nov 25 | atFGCU | 7:00 PM | 1-1 | .500 | - | | Alico Arena · Fort Myers, FL |
| 9 | Wed Nov 26 | vsOral Roberts | 4:30 PM | 0-1 | .000 | - | | Alico Arena · Fort Myers, FL |
| 10 | Wed Dec 3 | vsTexas St | 9:00 PM | 1-1 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 11 | Sat Dec 13 | vsArkansas St | 3:00 PM | 1-1 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 12 | Wed Dec 17 | vsTBD | 12:15 PM | 0-0 | .000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 13 | Sat Dec 20 | atPepperdine | 9:00 PM | 1-1 | .500 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 14 | Wed Dec 31 | atTulsa | 2:00 PM | 2-0 | 1.000 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sat Jan 3 | vsMemphis | 3:00 PM | 0-0 | .000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 16 | Wed Jan 7 | atWichita St | 7:30 PM | 1-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 17 | Sun Jan 11 | vsCharlotte | 2:00 PM | 2-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 18 | Wed Jan 14 | atUTSA | 8:00 PM | 1-1 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 19 | Wed Jan 21 | vsTemple | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 20 | Sun Jan 25 | vsTulsa | 4:00 PM | 2-0 | 1.000 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 21 | Wed Jan 28 | atE Carolina | 7:00 PM | 1-0 | 1.000 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sat Jan 31 | atCharlotte | 6:00 PM | 2-0 | 1.000 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 23 | Wed Feb 4 | vsNorth Texas | 8:00 PM | 2-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 24 | Sun Feb 8 | atUAB | 3:00 PM | 1-1 | .500 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 25 | Wed Feb 11 | vsFAU | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 26 | Sat Feb 14 | vsE Carolina | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 27 | Sun Feb 22 | atTulane | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 28 | Wed Feb 25 | vsSouth Florida | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 29 | Sun Mar 1 | atTemple | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 30 | Wed Mar 4 | atNorth Texas | 8:00 PM | 2-0 | 1.000 | - | ESPN+ | The Super Pit · Denton, TX |
| 31 | Sun Mar 8 | vsUTSA | 3:00 PM | 1-1 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
