| 1 | Mon Nov 7 | at Pepperdine | L67-106 | 0-1 | .000 | - | | Firestone Fieldhouse · Malibu, CA |
| 2 | Thu Nov 10 | vs TBD | W85-48 | 1-1 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 3 | Tue Nov 15 | at MTSU | L46-81 | 1-2 | .333 | - | | Murphy Center · Murfreesboro, TN |
| 4 | Fri Nov 18 | vs Georgia So | W88-71 | 2-2 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 5 | Sat Nov 19 | vs W Michigan | W96-88 | 3-2 | .600 | - | | Tudor Fieldhouse · Houston, TX |
| 6 | Mon Nov 21 | vs Hou Christian | W76-67 | 4-2 | .667 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Wed Nov 30 | vs Prairie View | W70-62 | 5-2 | .714 | - | | Tudor Fieldhouse · Houston, TX |
| 8 | Sun Dec 4 | at Texas St | W83-71 | 6-2 | .750 | - | | Strahan Arena at the University Events Center · San Marcos, TX |
| 9 | Mon Dec 12 | at #7Texas | L81-87 (OT) | 6-3 | .667 | - | LHN | Moody Center · Austin, TX |
| 10 | Thu Dec 15 | vsTBD | W92-54 | 7-3 | .700 | - | | Tudor Fieldhouse · Houston, TX |
| 11 | Sat Dec 17 | vs N'Western St | W110-73 | 8-3 | .727 | - | | Tudor Fieldhouse · Houston, TX |
| 12 | Mon Dec 19 | vsTBD | W109-64 | 9-3 | .750 | - | | Tudor Fieldhouse · Houston, TX |
| 13 | Thu Dec 29 | at Western KY | W81-78 | 10-3 | .769 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 14 | Sat Dec 31 | at UTEP | W72-67 (OT) | 11-3 | .786 | - | | Don Haskins Center · El Paso, TX |
| 15 | Thu Jan 5 | vs Louisiana Tech | L82-88 (OT) | 11-4 | .733 | - | | Tudor Fieldhouse · Houston, TX |
| 16 | Wed Jan 11 | vsMTSU | L68-71 | 11-5 | .688 | - | | Tudor Fieldhouse · Houston, TX |
| 17 | Sat Jan 14 | vsUTEP | W83-82 | 12-5 | .706 | - | | Tudor Fieldhouse · Houston, TX |
| 18 | Mon Jan 16 | at UTSA | W88-81 (OT) | 13-5 | .722 | - | | UTSA Convocation Center · San Antonio, TX |
| 19 | Thu Jan 19 | at North Texas | W72-60 | 14-5 | .737 | - | | The Super Pit · Denton, TX |
| 20 | Thu Jan 26 | vs Charlotte | W65-63 | 15-5 | .750 | - | | Tudor Fieldhouse · Houston, TX |
| 21 | Sat Jan 28 | vs UAB | L52-70 | 15-6 | .714 | - | | Tudor Fieldhouse · Houston, TX |
| 22 | Thu Feb 2 | atLouisiana Tech | L72-80 | 15-7 | .682 | - | | Thomas Assembly Center · Ruston, LA |
| 23 | Sat Feb 4 | vsNorth Texas | L64-74 | 15-8 | .652 | - | | Tudor Fieldhouse · Houston, TX |
| 24 | Thu Feb 9 | at FAU | L81-90 | 15-9 | .625 | - | | FAU Arena · Boca Raton, FL |
| 25 | Sat Feb 11 | at FIU | W85-78 | 16-9 | .640 | - | | Ocean Bank Convocation Center · Miami, FL |
| 26 | Thu Feb 16 | vsUTSA | L79-84 | 16-10 | .615 | - | | Tudor Fieldhouse · Houston, TX |
| 27 | Sat Feb 18 | vsWestern KY | W83-77 | 17-10 | .630 | - | | Tudor Fieldhouse · Houston, TX |
| 28 | Thu Feb 23 | atUAB | L57-85 | 17-11 | .607 | - | | Bartow Arena · Birmingham, AL |
| 29 | Sat Feb 25 | atCharlotte | L54-70 | 17-12 | .586 | - | | Dale F. Halton Arena · Charlotte, NC |
| 30 | Thu Mar 2 | vsFAU | L74-103 | 17-13 | .567 | - | | Tudor Fieldhouse · Houston, TX |
| 31 | Sat Mar 4 | vsFIU | L83-90 | 17-14 | .548 | - | | Tudor Fieldhouse · Houston, TX |
| 32 | Wed Mar 8 | vsUTSA | W72-71 | 18-14 | .563 | - | | Tudor Fieldhouse · Houston, TX |
| 33 | Thu Mar 9 | atUAB | L60-87 | 18-15 | .545 | - | | Bartow Arena · Birmingham, AL |
| 34 | Sun Mar 19 | vs Duquesne | W84-78 | 19-15 | .559 | - | | Tudor Fieldhouse · Houston, TX |
| 35 | Mon Mar 20 | vs Southern Utah | L79-81 | 19-16 | .543 | - | | Tudor Fieldhouse · Houston, TX |
