| 1 | Mon Nov 4 | vs TBD | W97-70 | 1-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Sat Nov 9 | vs Coast Car | W63-59 | 2-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 3 | Tue Nov 12 | vsTBD | W110-73 | 3-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Sat Nov 16 | vs George Mason | W78-77 (2OT) | 4-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 5 | Thu Nov 21 | at J'Ville St | L78-86 | 4-1 | .800 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 6 | Fri Nov 22 | at Stetson | W71-64 | 5-1 | .833 | - | | Edmunds Center · Deland, FL |
| 7 | Sat Nov 23 | at UIC | W72-55 | 6-1 | .857 | - | | Credit Union 1 Arena · Chicago, IL |
| 8 | Fri Nov 29 | vs NC A&T | W93-69 | 7-1 | .875 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Tue Dec 3 | vs UNC Wilmington | L53-67 | 7-2 | .778 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Sat Dec 7 | at South Carolina | L68-75 | 7-3 | .700 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 11 | Wed Dec 11 | vs North Alabama | L67-74 | 7-4 | .636 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Tue Dec 17 | vs FIU | W75-64 | 8-4 | .667 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 13 | Sat Dec 21 | vs Gardner-Webb | L79-84 | 8-5 | .615 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Tue Dec 31 | at South Florida | L69-75 | 8-6 | .571 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 15 | Sun Jan 5 | vs FAU | L76-78 | 8-7 | .533 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 16 | Wed Jan 8 | vs Temple | W80-79 | 9-7 | .563 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Sat Jan 11 | at #19Memphis | L70-74 | 9-8 | .529 | - | ESPN+ | FedExForum · Memphis, TN |
| 18 | Tue Jan 14 | vs North Texas | L60-69 | 9-9 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Sat Jan 18 | at Wichita St | W75-72 | 10-9 | .526 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 20 | Tue Jan 21 | at Tulsa | W85-76 (OT) | 11-9 | .550 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Sat Jan 25 | vsSouth Florida | W64-55 | 12-9 | .571 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sat Feb 1 | atTemple | L94-98 (OT) | 12-10 | .545 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 23 | Wed Feb 5 | vs Rice | L60-73 | 12-11 | .522 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Sat Feb 8 | at UTSA | W80-79 | 13-11 | .542 | - | ESPNU | UTSA Convocation Center · San Antonio, TX |
| 25 | Tue Feb 11 | vs UAB | W82-75 | 14-11 | .560 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 26 | Sat Feb 15 | at Charlotte | W75-59 | 15-11 | .577 | - | ESPNEWS | Dale F. Halton Arena · Charlotte, NC |
| 27 | Wed Feb 19 | at Tulane | L81-86 | 15-12 | .556 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
