| 2 | Sat Nov 8 | at Richmond | 6:00 PM | 1-0 | 1.000 | - | ESPN+ | Robins Center · Richmond, VA |
| 3 | Thu Nov 13 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Tue Nov 18 | atUNC Wilmington | 7:00 PM | 1-0 | 1.000 | - | | Trask Coliseum · Wilmington, NC |
| 5 | Fri Nov 21 | vsCharleston So | 7:00 PM | 1-1 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 6 | Tue Nov 25 | vs#22Michigan St | 1:00 PM | 1-0 | 1.000 | - | FS2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Thu Nov 27 | vsSt Bonaventure | 12:00 PM | 1-0 | 1.000 | - | FS1 | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Tue Dec 2 | vsMD-Eastern | 7:00 PM | 0-2 | .000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Sat Dec 6 | vsUNC Greensboro | 4:00 PM | 0-1 | .000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Thu Dec 11 | vsAppalachian St | 7:00 PM | 1-1 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 11 | Sun Dec 14 | vsBuffalo | 1:00 PM | 2-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Wed Dec 17 | vsPresbyterian | 7:00 PM | 1-1 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 13 | Mon Dec 22 | at#25UNC | 8:00 PM | 2-0 | 1.000 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Wed Dec 31 | vsTulane | 12:00 PM | 2-0 | 1.000 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 15 | Wed Jan 7 | atTemple | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 16 | Sun Jan 11 | vsUAB | 2:00 PM | 1-1 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Wed Jan 14 | atSouth Florida | 7:00 PM | 1-1 | .500 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 18 | Sun Jan 18 | vsCharlotte | 2:00 PM | 2-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Wed Jan 21 | atWichita St | 7:30 PM | 1-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 20 | Sat Jan 24 | atNorth Texas | 6:00 PM | 2-0 | 1.000 | - | ESPN+ | The Super Pit · Denton, TX |
| 21 | Wed Jan 28 | vsRice | 7:00 PM | 1-1 | .500 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sun Feb 1 | atFAU | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 23 | Sat Feb 7 | vsTemple | 12:00 PM | 1-0 | 1.000 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Wed Feb 11 | vsUTSA | 7:00 PM | 1-1 | .500 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 25 | Sat Feb 14 | atRice | 2:00 PM | 1-1 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 26 | Wed Feb 18 | vsWichita St | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Sat Feb 21 | atCharlotte | 12:00 PM | 2-0 | 1.000 | - | | Dale F. Halton Arena · Charlotte, NC |
| 28 | Wed Feb 25 | atUTSA | 8:00 PM | 1-1 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 29 | Sun Mar 1 | vsMemphis | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Thu Mar 5 | vsTulsa | 7:00 PM | 2-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 31 | Sun Mar 8 | atUAB | 3:00 PM | 1-1 | .500 | - | ESPN+ | Bartow Arena · Birmingham, AL |
