| 1 | Tue Nov 4 | vs Georgia So | W92-89 | 1-0 | 1.000 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Sat Nov 8 | atRichmond | L72-87 | 1-1 | .500 | - | ESPN+ | Robins Center · Richmond, VA |
| 3 | Thu Nov 13 | vsTBD | W71-70 | 2-1 | .667 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Tue Nov 18 | atUNC Wilmington | L60-85 | 2-2 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 5 | Fri Nov 21 | vsCharleston So | L65-77 | 2-3 | .400 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 6 | Tue Nov 25 | vs11Michigan St | L56-89 | 2-4 | .333 | - | FS2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Thu Nov 27 | vsSt Bonaventure | L58-67 | 2-5 | .286 | - | FS1 | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Tue Dec 2 | vsMD-Eastern | W68-56 | 3-5 | .375 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Sat Dec 6 | vsUNC Greensboro | L78-82 | 3-6 | .333 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Thu Dec 11 | vsAppalachian St | L54-67 | 3-7 | .300 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 11 | Sun Dec 14 | vsBuffalo | W73-70 | 4-7 | .364 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Wed Dec 17 | vsPresbyterian | W74-53 | 5-7 | .417 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 13 | Mon Dec 22 | at12UNC | L51-99 | 5-8 | .385 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Wed Dec 31 | vsTulane | L70-79 | 5-9 | .357 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 15 | Wed Jan 7 | atTemple | L67-75 | 5-10 | .333 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 16 | Sun Jan 11 | vsUAB | L85-87 (OT) | 5-11 | .313 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Wed Jan 14 | atSouth Florida | L71-82 | 5-12 | .294 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 18 | Sun Jan 18 | vsCharlotte | L70-73 | 5-13 | .278 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Wed Jan 21 | atWichita St | L60-77 | 5-14 | .263 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 20 | Fri Jan 23 | atNorth Texas | W63-59 | 6-14 | .300 | - | ESPN+ | The Super Pit · Denton, TX |
| 21 | Wed Jan 28 | vsRice | L77-83 | 6-15 | .286 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sun Feb 1 | atFAU | W76-75 | 7-15 | .318 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 23 | Sat Feb 7 | vsTemple | L73-81 | 7-16 | .304 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Wed Feb 11 | vsUTSA | W88-72 | 8-16 | .333 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 25 | Sat Feb 14 | atRice | W85-75 | 9-16 | .360 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 26 | Wed Feb 18 | vsWichita St | L89-92 (2OT) | 9-17 | .346 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Sat Feb 21 | atCharlotte | L56-68 | 9-18 | .333 | - | ESPN2 | Dale F. Halton Arena · Charlotte, NC |
| 28 | Wed Feb 25 | atUTSA | W82-81 | 10-18 | .357 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 29 | Sun Mar 1 | vsMemphis | W84-68 | 11-18 | .379 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
