| 1 | Tue Nov 8 | vs Mercer | W77-75 | 1-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Sat Nov 12 | vsPresbyterian | W77-57 | 2-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 3 | Wed Nov 16 | vsHampton | W82-73 | 3-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Mon Nov 21 | vsIndiana St | L75-79 | 3-1 | .750 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 5 | Tue Nov 22 | atToledo | W86-75 | 4-1 | .800 | - | | Savage Arena · Toledo, OH |
| 6 | Wed Nov 23 | vsUT Arlington | W79-65 | 5-1 | .833 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Sat Nov 26 | atOld Dominion | L50-71 | 5-2 | .714 | - | | Chartway Arena · Norfolk, VA |
| 8 | Tue Nov 29 | vsSC State | L68-73 | 5-3 | .625 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Fri Dec 2 | vsCampbell | W79-69 | 6-3 | .667 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Tue Dec 6 | atUNC Wilmington | L61-74 | 6-4 | .600 | - | | Trask Coliseum · Wilmington, NC |
| 11 | Sun Dec 11 | vsCoppin St | W84-75 | 7-4 | .636 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Sat Dec 17 | atSouth Carolina | W64-56 | 8-4 | .667 | - | | Colonial Life Arena · Columbia, SC |
| 13 | Wed Dec 21 | vsHigh Point | W60-49 | 9-4 | .692 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Wed Dec 28 | vsTemple | L57-59 | 9-5 | .643 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 15 | Sat Dec 31 | atWichita St | W79-69 | 10-5 | .667 | - | | Charles Koch Arena · Wichita, KS |
| 16 | Wed Jan 4 | vsUCF | L61-64 | 10-6 | .625 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Sat Jan 7 | atMemphis | L59-69 | 10-7 | .588 | - | | FedExForum · Memphis, TN |
| 18 | Wed Jan 11 | atCincinnati | L55-83 | 10-8 | .556 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Sun Jan 15 | vsSouth Florida | L70-81 | 10-9 | .526 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 20 | Wed Jan 18 | atTemple | L58-73 | 10-10 | .500 | - | | Liacouras Center · Philadelphia, PA |
| 21 | Tue Jan 24 | vsTulsa | W76-66 | 11-10 | .524 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sun Jan 29 | vsWichita St | L72-85 | 11-11 | .500 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 23 | Wed Feb 1 | atSouth Florida | L63-71 | 11-12 | .478 | - | ESPNU | Yuengling Center · Tampa, FL |
| 24 | Sat Feb 4 | vsSMU | W77-72 | 12-12 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 25 | Sat Feb 11 | atTulane | PPD | 16-17 | .485 | - | | Devlin Fieldhouse · New Orleans, LA |
| 26 | Wed Feb 15 | vsCincinnati | W75-71 | 13-12 | .520 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Sun Feb 19 | atSMU | L70-86 | 13-13 | .500 | - | | Moody Coliseum · Dallas, TX |
| 28 | Tue Feb 21 | atTulsa | W62-60 | 14-13 | .519 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 29 | Sat Feb 25 | vs#1Houston | L57-76 | 14-14 | .500 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Wed Mar 1 | vsTulane | W83-68 | 15-14 | .517 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 31 | Fri Mar 3 | atTulane | L78-81 | 15-15 | .500 | - | | Devlin Fieldhouse · New Orleans, LA |
| 32 | Sun Mar 5 | atUCF | L58-84 | 15-16 | .484 | - | | Addition Financial Arena · Orlando, FL |
| 33 | Thu Mar 9 | atSouth Florida | W73-58 | 16-16 | .500 | - | ESPNU | Yuengling Center · Tampa, FL |
| 34 | Fri Mar 10 | atHouston | L46-60 | 16-17 | .485 | - | ESPN2 | Fertitta Center · Houston, TX |
