| 1 | Mon Nov 6 | vs TBD | W91-61 | 1-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Sat Nov 11 | vs Campbell | W77-63 | 2-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 3 | Wed Nov 15 | vs SC Upstate | L81-83 | 2-1 | .667 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 4 | Sun Nov 19 | vs Northeastern | L76-82 | 2-2 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 5 | Mon Nov 20 | vs Georgia So | W82-64 | 3-2 | .600 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 6 | Tue Nov 21 | vs Kennesaw St | W85-84 | 4-2 | .667 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Sat Nov 25 | at George Mason | L59-81 | 4-3 | .571 | - | | EagleBank Arena · Fairfax, VA |
| 8 | Thu Nov 30 | vs UNC Wilmington | W74-66 | 5-3 | .625 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Mon Dec 4 | vs MD-Eastern | W63-52 | 6-3 | .667 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Sat Dec 9 | vs South Carolina | L62-68 | 6-4 | .600 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 11 | Thu Dec 14 | at Florida | L65-70 | 6-5 | .545 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 12 | Wed Dec 20 | vs Delaware St | W79-50 | 7-5 | .583 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 13 | Fri Dec 29 | vs ETSU | L70-86 | 7-6 | .538 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Tue Jan 2 | at #17FAU | L64-79 | 7-7 | .500 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 15 | Sun Jan 7 | vs Tulsa | W62-57 | 8-7 | .533 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 16 | Wed Jan 10 | at Temple | W73-62 | 9-7 | .563 | - | | Liacouras Center · Philadelphia, PA |
| 17 | Sat Jan 13 | vs SMU | L64-75 | 9-8 | .529 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 18 | Wed Jan 17 | vs North Texas | L59-60 | 9-9 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Sat Jan 20 | at UAB | L61-69 | 9-10 | .474 | - | | Bartow Arena · Birmingham, AL |
| 20 | Wed Jan 24 | at Wichita St | W54-52 | 10-10 | .500 | - | | Charles Koch Arena · Wichita, KS |
| 21 | Sun Jan 28 | vsTemple | W70-64 (OT) | 11-10 | .524 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Wed Jan 31 | vs South Florida | L60-71 | 11-11 | .500 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 23 | Sat Feb 3 | at Charlotte | L52-67 | 11-12 | .478 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 24 | Sat Feb 10 | at UTSA | W84-73 | 12-12 | .500 | - | ESPNU | UTSA Convocation Center · San Antonio, TX |
| 25 | Thu Feb 15 | vsWichita St | W68-55 | 13-12 | .520 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 26 | Sun Feb 18 | vs Tulane | W81-67 | 14-12 | .538 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Sat Feb 24 | at Rice | L52-70 | 14-13 | .519 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 28 | Thu Feb 29 | vs Memphis | L58-82 | 14-14 | .500 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 29 | Sun Mar 3 | atNorth Texas | L69-84 | 14-15 | .483 | - | | The Super Pit · Denton, TX |
| 30 | Wed Mar 6 | atSMU | L77-80 (OT) | 14-16 | .467 | - | | Moody Coliseum · Dallas, TX |
| 31 | Sat Mar 9 | vsCharlotte | L72-82 | 14-17 | .452 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 32 | Thu Mar 14 | vsTulsa | W84-79 | 15-17 | .469 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 33 | Fri Mar 15 | atSouth Florida | L59-81 | 15-18 | .455 | - | ESPN2 | Yuengling Center · Tampa, FL |
