| 1 | Tue Nov 5 | vs VMI | W80-68 | 1-0 | 1.000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 2 | Fri Nov 8 | atNavy | L57-62 | 1-1 | .500 | - | CBS | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Tue Nov 12 | atAppalachian St | L62-68 | 1-2 | .333 | - | | Holmes Convocation Center · Boone, NC |
| 4 | Sat Nov 16 | vsLiberty | L57-77 | 1-3 | .250 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 5 | Fri Nov 22 | atEvansville | W85-68 | 2-3 | .400 | - | | Ford Center · Evansville, IN |
| 6 | Sat Nov 23 | vsKansas City | L68-74 | 2-4 | .333 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Sun Nov 24 | atRice | L69-77 | 2-5 | .286 | - | | Tudor Fieldhouse · Houston, TX |
| 8 | Sat Nov 30 | atJMU | L89-99 | 2-6 | .250 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 9 | Tue Dec 3 | vsCoppin St | L75-85 | 2-7 | .222 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Sat Dec 14 | vsCampbell | W79-67 | 3-7 | .300 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 11 | Tue Dec 17 | vsMD-Eastern | W71-57 | 4-7 | .364 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 12 | Sun Dec 22 | vsCharlotte | W60-56 | 5-7 | .417 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 13 | Sat Dec 28 | vsE Kentucky | W82-74 | 6-7 | .462 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Wed Jan 1 | at#24Wichita St | L69-75 | 6-8 | .429 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 15 | Tue Jan 7 | vsSouth Florida | W62-59 | 7-8 | .467 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 16 | Sat Jan 11 | vsSMU | W71-68 | 8-8 | .500 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Wed Jan 15 | vsTulsa | L49-65 | 8-9 | .471 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 18 | Sun Jan 19 | atCincinnati | L57-82 | 8-10 | .444 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Wed Jan 22 | atSMU | L64-84 | 8-11 | .421 | - | | Moody Coliseum · Dallas, TX |
| 20 | Sat Jan 25 | vsTulane | W81-62 | 9-11 | .450 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 21 | Wed Jan 29 | vs#21Houston | L59-69 | 9-12 | .429 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sat Feb 1 | atTemple | L64-76 | 9-13 | .409 | - | CBS | Liacouras Center · Philadelphia, PA |
| 23 | Thu Feb 6 | vsUCF | L64-68 | 9-14 | .391 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Sat Feb 8 | atTulane | W81-67 | 10-14 | .417 | - | ESPNU | Devlin Fieldhouse · New Orleans, LA |
| 25 | Wed Feb 12 | atTulsa | L56-70 | 10-15 | .400 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 26 | Sun Feb 16 | vsCincinnati | L67-70 (OT) | 10-16 | .385 | - | CBS | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Wed Feb 19 | atMemphis | L73-77 | 10-17 | .370 | - | CBS | FedExForum · Memphis, TN |
| 28 | Sun Feb 23 | vsTemple | W67-63 | 11-17 | .393 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 29 | Wed Feb 26 | atSouth Florida | L68-73 (OT) | 11-18 | .379 | - | | Yuengling Center · Tampa, FL |
| 30 | Sat Feb 29 | vsUConn | L63-84 | 11-19 | .367 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 31 | Sun Mar 8 | atUCF | L62-94 | 11-20 | .355 | - | ESPNU | Addition Financial Arena · Orlando, FL |
