| 1 | Mon Nov 4 | vs Tarleton | W96-62 | 1-0 | 1.000 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 2 | Thu Nov 7 | vs FAMU | W102-73 | 2-0 | 1.000 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 3 | Mon Nov 11 | vs UNC Greensboro | W81-68 | 3-0 | 1.000 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 4 | Fri Nov 15 | at Butler | L70-81 | 3-1 | .750 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Mon Nov 18 | vs Prairie View | W110-69 | 4-1 | .800 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 6 | Fri Nov 22 | vs Mississippi St | L79-84 | 4-2 | .667 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 7 | Tue Nov 26 | vs CA Baptist | W79-77 | 5-2 | .714 | - | truTV | Moody Coliseum · Dallas, TX |
| 8 | Wed Nov 27 | at Washington St | W77-60 | 6-2 | .750 | - | | Friel Court at Beasley Coliseum · Pullman, WA |
| 9 | Tue Dec 3 | vs Alabama St | W101-72 | 7-2 | .778 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 10 | Sat Dec 7 | vs Virginia | W63-51 | 8-2 | .800 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 11 | Sat Dec 14 | vs LSU | W74-64 | 9-2 | .818 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 12 | Sat Dec 21 | at Boston College | W103-77 | 10-2 | .833 | - | The CW Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Sun Dec 29 | vs Longwood | W98-82 | 11-2 | .846 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 14 | Sat Jan 4 | vs #4Duke | L62-89 | 11-3 | .786 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 15 | Tue Jan 7 | at UNC | L67-82 | 11-4 | .733 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Sat Jan 11 | vs Georgia Tech | W93-71 | 12-4 | .750 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 17 | Wed Jan 15 | atVirginia | W54-52 | 13-4 | .765 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 18 | Sat Jan 18 | at Miami | W117-74 | 14-4 | .778 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 19 | Tue Jan 21 | vs #25Louisville | L73-98 | 14-5 | .737 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 20 | Sat Jan 25 | at NC State | W63-57 | 15-5 | .750 | - | The CW Network | PNC Arena · Raleigh, NC |
| 21 | Wed Jan 29 | vs California | W76-65 | 16-5 | .762 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 22 | Sat Feb 1 | vs Stanford | W85-61 | 17-5 | .773 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 23 | Wed Feb 5 | at Virginia Tech | W81-75 | 18-5 | .783 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 24 | Tue Feb 11 | vs Pitt | W83-63 | 19-5 | .792 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 25 | Sat Feb 15 | vs Wake Forest | L66-77 | 19-6 | .760 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 26 | Wed Feb 19 | at Notre Dame | W97-73 | 20-6 | .769 | - | ACC Network | Purcell Pavilion · South Bend, IN |
#18Clemson
Syracuse
Florida St