| 1 | Mon Nov 6 | vs TBD | W82-63 | 1-0 | 1.000 | - | | Moody Coliseum · Dallas, TX |
| 2 | Wed Nov 8 | vsW Illinois | W90-53 | 2-0 | 1.000 | - | | Moody Coliseum · Dallas, TX |
| 3 | Thu Nov 9 | vsLamar | W78-67 | 3-0 | 1.000 | - | | Moody Coliseum · Dallas, TX |
| 4 | Tue Nov 14 | vs13Texas A&M | L66-79 | 3-1 | .750 | - | | Moody Coliseum · Dallas, TX |
| 5 | Mon Nov 20 | atWest Virginia | W70-58 | 4-1 | .800 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 6 | Wed Nov 22 | vsWisconsin | L61-69 | 4-2 | .667 | - | FS1 | Moody Coliseum · Dallas, TX |
| 7 | Sun Nov 26 | vsUL Monroe | W70-57 | 5-2 | .714 | - | | Moody Coliseum · Dallas, TX |
| 8 | Wed Nov 29 | vsDayton | L63-65 | 5-3 | .625 | - | | Moody Coliseum · Dallas, TX |
| 9 | Sun Dec 3 | vsE Texas A&M | W90-47 | 6-3 | .667 | - | | Moody Coliseum · Dallas, TX |
| 10 | Wed Dec 6 | atArizona St | L74-76 | 6-4 | .600 | - | FS1 | Desert Financial Arena · Tempe, AZ |
| 11 | Sat Dec 16 | atFlorida St | W68-57 | 7-4 | .636 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Tue Dec 19 | vsHou Christian | W89-53 | 8-4 | .667 | - | | Moody Coliseum · Dallas, TX |
| 13 | Fri Dec 22 | atMurray St | W92-65 | 9-4 | .692 | - | CBSSN | CFSB Center · Murray, KY |
| 14 | Tue Jan 2 | vsCharlotte | W66-54 | 10-4 | .714 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 15 | Sun Jan 7 | at15Memphis | L59-62 | 10-5 | .667 | - | ESPN | FedExForum · Memphis, TN |
| 16 | Sat Jan 13 | atE Carolina | W75-64 | 11-5 | .688 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 17 | Tue Jan 16 | vsTemple | W77-64 | 12-5 | .706 | - | | Moody Coliseum · Dallas, TX |
| 18 | Sat Jan 20 | vsTulsa | W103-70 | 13-5 | .722 | - | | Moody Coliseum · Dallas, TX |
| 19 | Thu Jan 25 | atNorth Texas | L66-68 | 13-6 | .684 | - | ESPN2 | The Super Pit · Denton, TX |
| 20 | Sun Jan 28 | atWichita St | L72-77 | 13-7 | .650 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 21 | Thu Feb 1 | vsTulane | W80-76 | 14-7 | .667 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 22 | Sun Feb 4 | vsUAB | W72-69 | 15-7 | .682 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 23 | Wed Feb 7 | atRice | W95-69 | 16-7 | .696 | - | | Tudor Fieldhouse · Houston, TX |
| 24 | Sun Feb 11 | vsNorth Texas | W71-68 | 17-7 | .708 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 25 | Thu Feb 15 | atTulane | W87-79 | 18-7 | .720 | - | | Devlin Fieldhouse · New Orleans, LA |
| 26 | Sun Feb 18 | vsMemphis | W106-79 | 19-7 | .731 | - | ESPN | Moody Coliseum · Dallas, TX |
| 27 | Thu Feb 22 | atFAU | L70-80 | 19-8 | .704 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 28 | Sun Feb 25 | atSouth Florida | L68-79 | 19-9 | .679 | - | ESPN2 | Yuengling Center · Tampa, FL |
| 29 | Sat Mar 2 | vsUTSA | L73-77 | 19-10 | .655 | - | | Moody Coliseum · Dallas, TX |
| 30 | Wed Mar 6 | vsE Carolina | W80-77 (OT) | 20-10 | .667 | - | | Moody Coliseum · Dallas, TX |
| 31 | Sun Mar 10 | atUAB | L70-74 | 20-11 | .645 | - | | Bartow Arena · Birmingham, AL |
| 32 | Thu Mar 14 | vsTemple | L60-75 | 20-12 | .625 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 33 | Wed Mar 20 | atIndiana St | L92-101 | 20-13 | .606 | - | | Hulman Center · Terre Haute, IN |
