| 1 | Tue Nov 9 | vs McNeese | W86-62 | -28½ | 1-0 | 1.000 | - | | Moody Coliseum · Dallas, TX |
| 2 | Fri Nov 12 | at13Oregon | L63-86 | +7½ | 1-1 | .500 | - | | Matthew Knight Arena · Eugene, OR |
| 3 | Mon Nov 15 | vsN'Western St | W95-48 | -20½ | 2-1 | .667 | - | | Moody Coliseum · Dallas, TX |
| 4 | Thu Nov 18 | vsSE Louisiana | W78-61 | -20 | 3-1 | .750 | - | | Moody Coliseum · Dallas, TX |
| 5 | Sun Nov 21 | vsMissouri | L75-80 (OT) | +7 | 3-2 | .600 | - | CBS Sports Network | UNF Arena · Jacksonville, FL |
| 6 | Mon Nov 22 | vsLMU | L70-76 | -4 | 3-3 | .500 | - | | UNF Arena · Jacksonville, FL |
| 7 | Wed Nov 24 | vsSam Houston | W75-66 | -12½ | 4-3 | .571 | - | | Moody Coliseum · Dallas, TX |
| 8 | Sun Nov 28 | vsUL Monroe | W74-67 | -16½ | 5-3 | .625 | - | | Moody Coliseum · Dallas, TX |
| 9 | Wed Dec 1 | vsUNLV | W83-64 | -8 | 6-3 | .667 | - | | Moody Coliseum · Dallas, TX |
| 10 | Sat Dec 4 | vsVanderbilt | W84-72 | -5½ | 7-3 | .700 | - | | Moody Coliseum · Dallas, TX |
| 11 | Wed Dec 8 | vsDayton | W77-69 | -4½ | 8-3 | .727 | - | | Moody Coliseum · Dallas, TX |
| 12 | Sun Dec 19 | atNew Mexico | W90-72 | -4 | 9-3 | .750 | - | | The Pit · Albuquerque, NM |
| 14 | Wed Dec 29 | atTulsa | W74-69 | -3½ | 10-3 | .769 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sun Jan 2 | vsUCF | W72-60 | -4 | 11-3 | .786 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 16 | Thu Jan 6 | atCincinnati | L60-77 | +2 | 11-4 | .733 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 17 | Wed Jan 12 | vsSouth Florida | W77-65 | -14½ | 12-4 | .750 | - | | Moody Coliseum · Dallas, TX |
| 18 | Sat Jan 15 | atTulane | W75-66 | -3 | 13-4 | .765 | - | | Devlin Fieldhouse · New Orleans, LA |
| 19 | Thu Jan 20 | atMemphis | W70-62 | +6 | 14-4 | .778 | - | ESPN2 | FedExForum · Memphis, TN |
| 20 | Sun Jan 23 | vsWichita St | PPD | - | 24-9 | .727 | - | | Moody Coliseum · Dallas, TX |
| 21 | Wed Jan 26 | atSouth Florida | W74-54 | -8½ | 15-4 | .789 | - | | Yuengling Center · Tampa, FL |
| 22 | Sat Jan 29 | vsTemple | W69-61 | -9½ | 16-4 | .800 | - | | Moody Coliseum · Dallas, TX |
| 24 | Sat Feb 5 | atWichita St | L57-72 | +1½ | 16-5 | .762 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 25 | Wed Feb 9 | vs6Houston | W85-83 | +7½ | 17-5 | .773 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 26 | Sat Feb 12 | atE Carolina | W80-66 | -6½ | 18-5 | .783 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 27 | Wed Feb 16 | atTemple | L57-64 | -3 | 18-6 | .750 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 28 | Sun Feb 20 | vsMemphis | W73-57 | +2½ | 19-6 | .760 | - | ESPN | Moody Coliseum · Dallas, TX |
| 29 | Wed Feb 23 | vsTulsa | W75-61 | -10½ | 20-6 | .769 | - | | Moody Coliseum · Dallas, TX |
| 30 | Sun Feb 27 | at14Houston | L61-75 | +11 | 20-7 | .741 | - | ESPN | Fertitta Center · Houston, TX |
| 31 | Thu Mar 3 | vsCincinnati | W76-71 | -7½ | 21-7 | .750 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 32 | Sun Mar 6 | vsTulane | W74-68 | -10 | 22-7 | .759 | - | | Moody Coliseum · Dallas, TX |
| 33 | Fri Mar 11 | vsTulsa | W83-58 | -9½ | 23-7 | .767 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 34 | Sat Mar 12 | vsMemphis | L63-70 | +4½ | 23-8 | .742 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 33 | Wed Mar 16 | vsNicholls | W68-58 | -14½ | 24-8 | .750 | - | | Moody Coliseum · Dallas, TX |
| 34 | Sun Mar 20 | vsWashington St | L63-75 | -3 | 24-9 | .727 | - | | Moody Coliseum · Dallas, TX |
