| 1 | Mon Nov 3 | vs Tarleton | W96-76 | 1-0 | 1.000 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 2 | Thu Nov 6 | vsTexas A&M-CC | W69-58 | 2-0 | 1.000 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 3 | Tue Nov 11 | vsMurray St | W102-91 | 3-0 | 1.000 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 4 | Sat Nov 15 | vsButler | W87-85 | 4-0 | 1.000 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 5 | Tue Nov 18 | vsAR-Pine Bluff | W106-60 | 5-0 | 1.000 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 6 | Fri Nov 21 | vsArkansas St | W100-69 | 6-0 | 1.000 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 7 | Mon Nov 24 | vsRadford | W89-72 | 7-0 | 1.000 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 8 | Fri Nov 28 | atMississippi St | W87-81 (OT) | 8-0 | 1.000 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 9 | Wed Dec 3 | at17Vanderbilt | L69-88 | 8-1 | .889 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 10 | Sun Dec 7 | vsTexas A&M | W93-80 (OT) | 9-1 | .900 | - | ESPN2 | College Park Center · Arlington, TX |
| 11 | Sat Dec 13 | atLSU | L77-89 | 9-2 | .818 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 12 | Sun Dec 21 | vsC Arkansas | W99-82 | 10-2 | .833 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 13 | Sun Dec 28 | vsFullerton | W110-63 | 11-2 | .846 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 14 | Sat Jan 3 | vs12UNC | W97-83 | 12-2 | .857 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 15 | Wed Jan 7 | atClemson | L70-74 | 12-3 | .800 | #24 | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 16 | Sat Jan 10 | at6Duke | L75-82 | 12-4 | .750 | #24 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 17 | Wed Jan 14 | vsVirginia Tech | W77-76 | 13-4 | .765 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 18 | Sat Jan 17 | vs16Virginia | L68-72 | 13-5 | .722 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 19 | Tue Jan 20 | atWake Forest | W91-79 | 14-5 | .737 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Sat Jan 24 | vsFlorida St | W83-80 | 15-5 | .750 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 21 | Sat Jan 31 | at20Louisville | L74-88 | 15-6 | .714 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 22 | Tue Feb 3 | vsNC State | L83-84 | 15-7 | .682 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 23 | Sat Feb 7 | atPitt | W86-67 | 16-7 | .696 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 24 | Tue Feb 10 | vsNotre Dame | W89-81 | 17-7 | .708 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 25 | Sat Feb 14 | atSyracuse | L78-79 | 17-8 | .680 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 26 | Tue Feb 17 | vs21Louisville | W95-85 | 18-8 | .692 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 27 | Sat Feb 21 | vsBoston College | W94-70 | 19-8 | .704 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 28 | Wed Feb 25 | atCalifornia | L69-73 | 19-9 | .679 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 29 | Sat Feb 28 | atStanford | L75-95 | 19-10 | .655 | - | ACC Network | Maples Pavilion · Stanford, CA |
