| 1 | Mon Nov 4 | vs Fairleigh | W113-72 | 1-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 2 | Sun Nov 10 | vs Binghamton | W88-64 | 2-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 3 | Sun Nov 17 | vs Coppin St | W93-63 | 3-0 | 1.000 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 4 | Thu Nov 21 | at Drake | L69-80 | 3-1 | .750 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 5 | Fri Nov 22 | at Oklahoma St | L74-80 | 3-2 | .600 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Sun Nov 24 | at VCU | L70-77 | 3-3 | .500 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 7 | Sat Nov 30 | vs Charleston So | L79-83 | 3-4 | .429 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 8 | Tue Dec 3 | vs Arkansas | L73-76 | 3-5 | .375 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 9 | Sat Dec 7 | vs Clemson | L55-65 | 3-6 | .333 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 10 | Tue Dec 10 | at #1Tennessee | L62-75 | 3-7 | .300 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sun Dec 15 | vs Presbyterian | W94-75 | 4-7 | .364 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 12 | Sat Dec 21 | vs Mount St Mary | L74-78 (OT) | 4-8 | .333 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 13 | Wed Jan 1 | at Boston College | L68-78 | 4-9 | .308 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Sat Jan 4 | at Virginia Tech | L85-86 | 4-10 | .286 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 15 | Wed Jan 8 | vs Florida St | L65-80 | 4-11 | .267 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Sat Jan 11 | vs Wake Forest | L78-88 | 4-12 | .250 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 17 | Tue Jan 14 | at #3Duke | L54-89 | 4-13 | .235 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 18 | vs SMU | L74-117 | 4-14 | .222 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 19 | Wed Jan 22 | at Stanford | L51-88 | 4-15 | .211 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 20 | Sat Jan 25 | at California | L94-98 (OT) | 4-16 | .200 | - | ESPNU | Haas Pavilion · Berkeley, CA |
| 21 | Wed Jan 29 | vs Virginia | L71-82 | 4-17 | .190 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 22 | Sat Feb 1 | vs Notre Dame | W63-57 | 5-17 | .227 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 8 | at Louisville | L78-88 | 5-18 | .217 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 24 | Tue Feb 11 | vs Syracuse | W91-84 | 6-18 | .250 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 15 | at Pitt | L65-74 | 6-19 | .240 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 26 | Wed Feb 19 | atFlorida St | L66-74 | 6-20 | .231 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
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