| 1 | Tue Nov 5 | vs 5Louisville | L74-87 | 0-1 | .000 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 2 | Fri Nov 8 | vsFAU | W74-60 | 1-1 | .500 | - | | Watsco Center · Coral Gables, FL |
| 3 | Tue Nov 12 | atUCF | W79-70 | 2-1 | .667 | - | CBSSN | Addition Financial Arena · Orlando, FL |
| 4 | Sat Nov 16 | vsQuinnipiac | W80-52 | 3-1 | .750 | - | | Watsco Center · Coral Gables, FL |
| 5 | Thu Nov 21 | vsMissouri St | W74-70 | 4-1 | .800 | - | ESPNU | TD Arena · Charleston, SC |
| 6 | Fri Nov 22 | atFlorida | L58-78 | 4-2 | .667 | - | ESPN2 | TD Arena · Charleston, SC |
| 7 | Sun Nov 24 | atUConn | L55-80 | 4-3 | .571 | - | ESPN2 | TD Arena · Charleston, SC |
| 8 | Mon Dec 2 | atIllinois | W81-79 | 5-3 | .625 | - | ESPN2 | State Farm Center · Champaign, IL |
| 9 | Sat Dec 14 | vsAlabama A&M | W88-74 | 6-3 | .667 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 10 | Tue Dec 17 | atTemple | W78-77 | 7-3 | .700 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 11 | Sat Dec 21 | vsCoppin St | W91-60 | 8-3 | .727 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 12 | Tue Dec 31 | atClemson | W73-68 (OT) | 9-3 | .750 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 13 | Sat Jan 4 | vs2Duke | L62-95 | 9-4 | .692 | - | ESPN | Watsco Center · Coral Gables, FL |
| 14 | Tue Jan 7 | at13Louisville | L58-74 | 9-5 | .643 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 15 | Sun Jan 12 | vsPitt | W66-58 | 10-5 | .667 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Wed Jan 15 | atNC State | L63-80 | 10-6 | .625 | - | | PNC Arena · Raleigh, NC |
| 17 | Sat Jan 18 | vs9Florida St | L79-83 (OT) | 10-7 | .588 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 18 | Tue Jan 21 | at8Duke | L59-89 | 10-8 | .556 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 19 | Sat Jan 25 | atUNC | L71-94 | 10-9 | .526 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Tue Jan 28 | vsVirginia Tech | W71-61 | 11-9 | .550 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 21 | Sun Feb 2 | atPitt | L57-62 | 11-10 | .524 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Wed Feb 5 | vsNC State | L72-83 | 11-11 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 8 | at8Florida St | L81-99 | 11-12 | .478 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 24 | Wed Feb 12 | vsBoston College | W85-58 | 12-12 | .500 | - | | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 15 | vsWake Forest | W71-54 | 13-12 | .520 | - | | Watsco Center · Coral Gables, FL |
| 26 | Wed Feb 19 | atVirginia Tech | W102-95 (3OT) | 14-12 | .538 | - | | Cassell Coliseum · Blacksburg, VA |
| 27 | Sun Feb 23 | atNotre Dame | L71-87 | 14-13 | .519 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 28 | Sat Feb 29 | atGeorgia Tech | L57-63 | 14-14 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 29 | Wed Mar 4 | vs22Virginia | L44-46 | 14-15 | .483 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 30 | Sat Mar 7 | vsSyracuse | W69-65 (OT) | 15-15 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 31 | Wed Mar 11 | atClemson | L64-69 | 15-16 | .484 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
