| 1 | Mon Nov 3 | vs Jacksonville | 8:00 PM | 19-14 | .576 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 2 | Thu Nov 6 | vsBethune | 7:00 PM | 17-16 | .515 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 3 | Mon Nov 10 | vsStetson | 7:00 PM | 8-24 | .250 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 4 | Sun Nov 16 | at#3Florida | 8:30 PM | 36-4 | .900 | - | ESPN | O'Connell Center · Gainesville, FL |
| 5 | Thu Nov 20 | vsElon | 7:00 PM | 17-16 | .515 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 6 | Sun Nov 23 | vsDelaware St | 1:00 PM | 16-14 | .533 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 7 | Thu Nov 27 | vs#8BYU | 5:00 PM | 26-10 | .722 | - | ESPN | Watsco Center · Coral Gables, FL |
| 8 | Tue Dec 2 | atOle Miss | 9:00 PM | 24-12 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 9 | Sat Dec 6 | vsSouthern Miss | 12:00 PM | 11-22 | .333 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 10 | Sat Dec 13 | vsUL Monroe | 12:00 PM | 7-25 | .219 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 11 | Tue Dec 16 | vsFIU | 7:00 PM | 10-23 | .303 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 12 | Sun Dec 21 | vsNorth Florida | 4:00 PM | 15-17 | .469 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 13 | Tue Dec 30 | vsPitt | 7:00 PM | 17-15 | .531 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 14 | Wed Jan 7 | atWake Forest | 7:00 PM | 21-11 | .656 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Sat Jan 10 | vsGeorgia Tech | 2:00 PM | 17-17 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Tue Jan 13 | atNotre Dame | 7:00 PM | 15-18 | .455 | - | | Purcell Pavilion · South Bend, IN |
| 17 | Sat Jan 17 | atClemson | 2:15 PM | 27-7 | .794 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 18 | Tue Jan 20 | vsFlorida St | 7:00 PM | 17-15 | .531 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 19 | Sat Jan 24 | atSyracuse | 2:00 PM | 14-19 | .424 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Wed Jan 28 | vsStanford | 9:00 PM | 21-14 | .600 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 21 | Sat Jan 31 | vsCalifornia | 4:00 PM | 14-19 | .424 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 22 | Sat Feb 7 | atBoston College | 2:00 PM | 12-19 | .387 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Tue Feb 10 | vs#25UNC | 7:00 PM | 23-14 | .622 | - | | Watsco Center · Coral Gables, FL |
| 24 | Sat Feb 14 | atNC State | 4:00 PM | 12-19 | .387 | - | | PNC Arena · Raleigh, NC |
| 25 | Tue Feb 17 | vsVirginia Tech | 8:00 PM | 13-19 | .406 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 26 | Sat Feb 21 | atVirginia | 2:00 PM | 15-17 | .469 | - | | John Paul Jones Arena · Charlottesville, VA |
| 27 | Tue Feb 24 | atFlorida St | 9:00 PM | 17-15 | .531 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 28 | Sat Feb 28 | vsBoston College | 2:00 PM | 12-19 | .387 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 29 | Wed Mar 4 | atSMU | 7:00 PM | 24-11 | .686 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 30 | Sat Mar 7 | vs#11Louisville | 2:00 PM | 27-8 | .771 | - | | Watsco Center · Coral Gables, FL |
