| 1 | Mon Nov 3 | vs Jacksonville | W86-69 | 1-0 | 1.000 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 2 | Thu Nov 6 | vsBethune | W101-61 | 2-0 | 1.000 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 3 | Mon Nov 10 | vsStetson | W102-61 | 3-0 | 1.000 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 4 | Sun Nov 16 | at10Florida | L68-82 | 3-1 | .750 | - | ESPN | O'Connell Center · Gainesville, FL |
| 5 | Thu Nov 20 | vsElon | W99-72 | 4-1 | .800 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 6 | Sun Nov 23 | vsDelaware St | W97-41 | 5-1 | .833 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 7 | Thu Nov 27 | vs9BYU | L62-72 | 5-2 | .714 | - | ESPN | Watsco Center · Coral Gables, FL |
| 8 | Fri Nov 28 | atGeorgetown | W78-65 | 6-2 | .750 | - | ESPN | Capital One Arena · Washington, D.C. |
| 9 | Tue Dec 2 | atOle Miss | W75-66 | 7-2 | .778 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 10 | Sat Dec 6 | vsSouthern Miss | W88-64 | 8-2 | .800 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 11 | Sat Dec 13 | vsUL Monroe | W104-79 | 9-2 | .818 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 12 | Tue Dec 16 | vsFIU | W98-81 | 10-2 | .833 | - | ACC Extra | Watsco Center · Coral Gables, FL |
| 13 | Sun Dec 21 | vsNorth Florida | W105-67 | 11-2 | .846 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 14 | Tue Dec 30 | vsPitt | W76-69 | 12-2 | .857 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Wed Jan 7 | atWake Forest | W81-77 | 13-2 | .867 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 16 | Sat Jan 10 | vsGeorgia Tech | W91-81 | 14-2 | .875 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 17 | Tue Jan 13 | atNotre Dame | W81-69 | 15-2 | .882 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 17 | at22Clemson | L59-69 | 15-3 | .833 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Tue Jan 20 | vsFlorida St | L63-65 | 15-4 | .789 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 20 | Sat Jan 24 | atSyracuse | W85-76 | 16-4 | .800 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Wed Jan 28 | vsStanford | W79-70 | 17-4 | .810 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 22 | Sat Jan 31 | vsCalifornia | L85-86 | 17-5 | .773 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 7 | atBoston College | W74-68 | 18-5 | .783 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Tue Feb 10 | vs11UNC | W75-66 | 19-5 | .792 | - | ESPN | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 14 | atNC State | W77-76 | 20-5 | .800 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 26 | Tue Feb 17 | vsVirginia Tech | W67-66 | 21-5 | .808 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 27 | Sat Feb 21 | at14Virginia | L83-86 | 21-6 | .778 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 28 | Tue Feb 24 | atFlorida St | W83-73 | 22-6 | .786 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Feb 28 | vsBoston College | W76-54 | 23-6 | .793 | - | ACC Network | Watsco Center · Coral Gables, FL |
