| 1 | Mon Nov 6 | vs NJIT | W101-60 | 1-0 | 1.000 | #13 | | Watsco Center · Coral Gables, FL |
| 2 | Fri Nov 10 | vs UCF | W88-72 | 2-0 | 1.000 | #13 | | Watsco Center · Coral Gables, FL |
| 3 | Mon Nov 13 | vs FIU | W86-80 | 3-0 | 1.000 | #12 | | Watsco Center · Coral Gables, FL |
| 4 | Fri Nov 17 | vs Georgia | W79-68 | 4-0 | 1.000 | #12 | CBS | Watsco Center · Coral Gables, FL |
| 5 | Sun Nov 19 | vs Kansas St | W91-83 | 5-0 | 1.000 | #12 | CBS | Watsco Center · Coral Gables, FL |
| 6 | Tue Nov 28 | at #12Kentucky | L73-95 | 5-1 | .833 | #8 | ESPN | Rupp Arena · Lexington, KY |
| 7 | Sat Dec 2 | vs Notre Dame | W62-49 | 6-1 | .857 | #8 | The CW Network | Watsco Center · Coral Gables, FL |
| 8 | Wed Dec 6 | vs Long Island | W97-49 | 7-1 | .875 | #15 | | Watsco Center · Coral Gables, FL |
| 9 | Sun Dec 10 | vs Colorado | L63-90 | 7-2 | .778 | #15 | ESPN2 | Watsco Center · Coral Gables, FL |
| 10 | Sat Dec 16 | vs La Salle | W84-77 | 8-2 | .800 | #24 | The CW Network | Watsco Center · Coral Gables, FL |
| 11 | Thu Dec 21 | vs Stonehill | W97-59 | 9-2 | .818 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 12 | Fri Dec 29 | vs North Florida | W95-55 | 10-2 | .833 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 13 | Wed Jan 3 | vs #16Clemson | W95-82 | 11-2 | .846 | - | ESPN | Watsco Center · Coral Gables, FL |
| 14 | Sat Jan 6 | at Wake Forest | L82-86 (OT) | 11-3 | .786 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Wed Jan 10 | vs Louisville | L71-80 | 11-4 | .733 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Sat Jan 13 | at Virginia Tech | W75-71 | 12-4 | .750 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 17 | Wed Jan 17 | vs Florida St | L75-84 | 12-5 | .706 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 18 | Sat Jan 20 | at Syracuse | L69-72 | 12-6 | .667 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 19 | Wed Jan 24 | atNotre Dame | W73-61 | 13-6 | .684 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 20 | Sat Jan 27 | vs Pitt | W72-68 | 14-6 | .700 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 21 | Tue Jan 30 | at NC State | L68-74 | 14-7 | .667 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 22 | Sat Feb 3 | vsVirginia Tech | W82-74 | 15-7 | .682 | - | ESPN | Watsco Center · Coral Gables, FL |
| 23 | Mon Feb 5 | at Virginia | L38-60 | 15-8 | .652 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 10 | vs #3UNC | L72-75 | 15-9 | .625 | - | ESPN | Watsco Center · Coral Gables, FL |
| 25 | Wed Feb 14 | atClemson | L60-77 | 15-10 | .600 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 26 | Sat Feb 17 | at Boston College | L77-85 | 15-11 | .577 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Wed Feb 21 | vs #8Duke | L55-84 | 15-12 | .556 | - | ESPN | Watsco Center · Coral Gables, FL |
| 28 | Sat Feb 24 | vs Georgia Tech | L76-80 | 15-13 | .536 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 29 | Mon Feb 26 | at#9UNC | L71-75 | 15-14 | .517 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Wed Mar 6 | vsBoston College | L57-67 | 15-15 | .500 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 31 | Sat Mar 9 | atFlorida St | L75-83 | 15-16 | .484 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 32 | Tue Mar 12 | atBoston College | L65-81 | 15-17 | .469 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
