| 1 | Mon Nov 7 | vs Lafayette | W67-54 | 1-0 | 1.000 | - | | Watsco Center · Coral Gables, FL |
| 2 | Fri Nov 11 | vs UNC Greensboro | W79-65 | 2-0 | 1.000 | - | | Watsco Center · Coral Gables, FL |
| 3 | Tue Nov 15 | vs FAMU | W87-61 | 3-0 | 1.000 | - | | Watsco Center · Coral Gables, FL |
| 4 | Sat Nov 19 | at Providence | W74-64 | 4-0 | 1.000 | - | ESPNEWS | Amica Mutual Pavilion · Providence, RI |
| 5 | Sun Nov 20 | at Maryland | L70-88 | 4-1 | .800 | - | ESPN | XFINITY Center · College Park, MD |
| 6 | Wed Nov 23 | vs St Francis BK | W79-56 | 5-1 | .833 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 7 | Sun Nov 27 | at UCF | W66-64 | 6-1 | .857 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 8 | Wed Nov 30 | vs Rutgers | W68-61 | 7-1 | .875 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 9 | Sun Dec 4 | at Louisville | W80-53 | 8-1 | .889 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 10 | Wed Dec 7 | vs Cornell | W107-105 | 9-1 | .900 | - | | Watsco Center · Coral Gables, FL |
| 11 | Sat Dec 10 | vs NC State | W80-73 | 10-1 | .909 | - | | Watsco Center · Coral Gables, FL |
| 12 | Sat Dec 17 | vs St Francis PA | W91-76 | 11-1 | .917 | #25 | | Watsco Center · Coral Gables, FL |
| 13 | Tue Dec 20 | vs #6Virginia | W66-64 | 12-1 | .923 | #22 | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Fri Dec 30 | at Notre Dame | W76-65 | 13-1 | .929 | #14 | ACC Network | Purcell Pavilion · South Bend, IN |
| 16 | Wed Jan 4 | at Georgia Tech | L70-76 | 13-2 | .867 | #12 | | McCamish Pavilion · Atlanta, GA |
| 17 | Wed Jan 11 | vs Boston College | W88-72 | 14-2 | .875 | #16 | ESPNU | Watsco Center · Coral Gables, FL |
| 18 | Sat Jan 14 | atNC State | L81-83 (OT) | 14-3 | .824 | #16 | | PNC Arena · Raleigh, NC |
| 19 | Mon Jan 16 | vs Syracuse | W82-78 | 15-3 | .833 | #17 | ACC Network | Watsco Center · Coral Gables, FL |
| 20 | Sat Jan 21 | at Duke | L66-68 | 15-4 | .789 | #17 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Tue Jan 24 | at Florida St | W86-63 | 16-4 | .800 | #20 | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 22 | Sat Jan 28 | at Pitt | L68-71 | 16-5 | .762 | #20 | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 23 | Tue Jan 31 | vs Virginia Tech | W92-83 | 17-5 | .773 | #23 | ESPNU | Watsco Center · Coral Gables, FL |
| 24 | Sat Feb 4 | at #20Clemson | W78-74 | 18-5 | .783 | #23 | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 25 | Mon Feb 6 | vsDuke | W81-59 | 19-5 | .792 | #19 | ESPN | Watsco Center · Coral Gables, FL |
| 26 | Sat Feb 11 | vsLouisville | W93-85 | 20-5 | .800 | #19 | ACC Network | Watsco Center · Coral Gables, FL |
| 27 | Mon Feb 13 | at UNC | W80-72 | 21-5 | .808 | #15 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 28 | Sat Feb 18 | vs Wake Forest | W96-87 | 22-5 | .815 | #15 | | Watsco Center · Coral Gables, FL |
| 29 | Tue Feb 21 | atVirginia Tech | W76-70 | 23-5 | .821 | #13 | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 30 | Sat Feb 25 | vsFlorida St | L84-85 | 23-6 | .793 | #13 | ESPN2 | Watsco Center · Coral Gables, FL |
| 31 | Sat Mar 4 | vs#25Pitt | W78-76 | 24-6 | .800 | #16 | ACC Network | Watsco Center · Coral Gables, FL |
| 32 | Thu Mar 9 | vsWake Forest | W74-72 | 25-6 | .806 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 33 | Fri Mar 10 | vsDuke | L78-85 | 25-7 | .781 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 34 | Fri Mar 17 | vs #12Drake | W63-56 | 26-7 | .788 | #5 | TBS | Watsco Center · Coral Gables, FL |
| 35 | Sun Mar 19 | at #4Indiana | W85-69 | 27-7 | .794 | #5 | TNT | Simon Skjodt Assembly Hall · Bloomington, IN |
| 36 | Fri Mar 24 | at #1Houston | W89-75 | 28-7 | .800 | #5 | CBS | Fertitta Center · Houston, TX |
| 37 | Sun Mar 26 | at #2Texas | W88-81 | 29-7 | .806 | #5 | CBS | Moody Center · Austin, TX |
| 38 | Sat Apr 1 | at #4UConn | L59-72 | 29-8 | .784 | #5 | CBS | Gampel Pavilion · Storrs, CT |
