| 1 | Sun Nov 29 | vs North Florida | W77-59 | 1-0 | 1.000 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 2 | Fri Dec 4 | vsStetson | W82-60 | 2-0 | 1.000 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 3 | Tue Dec 8 | vsPurdue | W58-54 | 3-0 | 1.000 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 4 | Sat Dec 12 | vsFGCU | L62-66 | 3-1 | .750 | - | | Watsco Center · Coral Gables, FL |
| 5 | Wed Dec 16 | vsPitt | L55-70 | 3-2 | .600 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 6 | Sat Dec 19 | vsJacksonville | W73-64 | 4-2 | .667 | - | | Watsco Center · Coral Gables, FL |
| 7 | Tue Dec 29 | at24Virginia Tech | L78-80 | 4-3 | .571 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 8 | Sat Jan 2 | vsClemson | L65-66 | 4-4 | .500 | - | | Watsco Center · Coral Gables, FL |
| 9 | Tue Jan 5 | vsUNC | L65-67 | 4-5 | .444 | - | ESPN | Watsco Center · Coral Gables, FL |
| 10 | Sat Jan 9 | atNC State | W64-59 | 5-5 | .500 | - | | PNC Arena · Raleigh, NC |
| 11 | Tue Jan 12 | atBoston College | L62-84 | 5-6 | .455 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sat Jan 16 | vs16Louisville | W78-72 | 6-6 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 13 | Tue Jan 19 | atSyracuse | L57-83 | 6-7 | .462 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Sun Jan 24 | vsNotre Dame | L59-73 | 6-8 | .429 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Wed Jan 27 | at16Florida St | L59-81 | 6-9 | .400 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 30 | atWake Forest | L54-66 | 6-10 | .375 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 17 | Mon Feb 1 | vsDuke | W77-75 | 7-10 | .412 | - | ESPN | Watsco Center · Coral Gables, FL |
| 18 | Sat Feb 6 | vs16Virginia Tech | L76-80 (OT) | 7-11 | .389 | - | | Watsco Center · Coral Gables, FL |
| 20 | Sun Feb 14 | atNotre Dame | L61-71 | 7-12 | .368 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 21 | Sat Feb 20 | vsGeorgia Tech | L60-87 | 7-13 | .350 | - | | Watsco Center · Coral Gables, FL |
| 22 | Wed Feb 24 | vs11Florida St | L71-88 | 7-14 | .333 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 27 | atClemson | L58-66 | 7-15 | .318 | - | | Littlejohn Coliseum · Clemson, SC |
| 24 | Mon Mar 1 | at21Virginia | L51-62 | 7-16 | .304 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 25 | Fri Mar 5 | vsBoston College | W80-76 | 8-16 | .333 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 26 | Tue Mar 9 | atPitt | W79-73 | 9-16 | .360 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 27 | Wed Mar 10 | atClemson | W67-64 | 10-16 | .385 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 28 | Thu Mar 11 | atGeorgia Tech | L66-70 | 10-17 | .370 | - | ESPN2 | Greensboro Coliseum · Greensboro, NC |
