| 1 | Tue Nov 9 | vs Canisius | W77-67 | 1-0 | 1.000 | - | | Watsco Center · Coral Gables, FL |
| 2 | Sat Nov 13 | vsUCF | L89-95 | 1-1 | .500 | - | | Watsco Center · Coral Gables, FL |
| 3 | Tue Nov 16 | atFAU | W68-66 | 2-1 | .667 | - | CBS | FAU Arena · Boca Raton, FL |
| 4 | Sun Nov 21 | vsFAMU | W86-59 | 3-1 | .750 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 5 | Thu Nov 25 | vsDayton | L60-76 | 3-2 | .600 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 6 | Fri Nov 26 | atNorth Texas | W69-63 | 4-2 | .667 | - | ESPN2 | The Super Pit · Denton, TX |
| 7 | Sun Nov 28 | atAlabama | L64-96 | 4-3 | .571 | - | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 8 | Wed Dec 1 | atPenn State | W63-58 | 5-3 | .625 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 9 | Sat Dec 4 | vsClemson | W80-75 | 6-3 | .667 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 10 | Wed Dec 8 | vsLipscomb | W76-59 | 7-3 | .700 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 11 | Sun Dec 12 | atFordham | W72-66 | 8-3 | .727 | - | | Rose Hill Gymnasium · Bronx, NY |
| 12 | Mon Dec 20 | vsStetson | W82-72 | 9-3 | .750 | - | | Watsco Center · Coral Gables, FL |
| 13 | Wed Dec 29 | vsNC State | W91-83 | 10-3 | .769 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 14 | Sat Jan 1 | vsWake Forest | W92-84 | 11-3 | .786 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 15 | Wed Jan 5 | vsSyracuse | W88-87 | 12-3 | .800 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 16 | Sat Jan 8 | at#2Duke | W76-74 | 13-3 | .813 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 17 | Tue Jan 11 | atFlorida St | L64-65 | 13-4 | .765 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Tue Jan 18 | vsUNC | W85-57 | 14-4 | .778 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 19 | Sat Jan 22 | vsFlorida St | L60-61 | 14-5 | .737 | - | ESPN | Watsco Center · Coral Gables, FL |
| 20 | Wed Jan 26 | atVirginia Tech | W78-75 | 15-5 | .750 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 21 | Sat Jan 29 | atGeorgia Tech | W73-62 | 16-5 | .762 | - | | McCamish Pavilion · Atlanta, GA |
| 22 | Wed Feb 2 | vsNotre Dame | L64-68 | 16-6 | .727 | - | | Watsco Center · Coral Gables, FL |
| 23 | Sat Feb 5 | atVirginia | L58-71 | 16-7 | .696 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Wed Feb 9 | vsGeorgia Tech | W79-70 | 17-7 | .708 | - | | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 12 | atWake Forest | W76-72 | 18-7 | .720 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 26 | Wed Feb 16 | atLouisville | W70-63 | 19-7 | .731 | - | | KFC Yum! Center · Louisville, KY |
| 27 | Sat Feb 19 | vsVirginia | L71-74 | 19-8 | .704 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 28 | Tue Feb 22 | atPitt | W85-64 | 20-8 | .714 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 29 | Sat Feb 26 | vsVirginia Tech | L70-71 | 20-9 | .690 | - | | Watsco Center · Coral Gables, FL |
| 30 | Wed Mar 2 | atBoston College | W81-70 | 21-9 | .700 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 31 | Sat Mar 5 | atSyracuse | W75-72 | 22-9 | .710 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 32 | Thu Mar 10 | vsBoston College | W71-69 (OT) | 23-9 | .719 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 33 | Fri Mar 11 | atDuke | L76-80 | 23-10 | .697 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 34 | Fri Mar 18 | at#7USC | W68-66 | 24-10 | .706 | #10 | truTV | Galen Center · Los Angeles, CA |
| 35 | Sun Mar 20 | at#2Auburn | W79-61 | 25-10 | .714 | #10 | truTV | Neville Arena · Auburn, AL |
| 36 | Fri Mar 25 | vs#11Iowa State | W70-56 | 26-10 | .722 | #10 | TBS | Watsco Center · Coral Gables, FL |
| 37 | Sun Mar 27 | at#1Kansas | L50-76 | 26-11 | .703 | #10 | CBS | Allen Fieldhouse · Lawrence, KS |
