| 1 | Mon Nov 3 | vs Bethune | W95-90 (OT) | 1-0 | 1.000 | #20 | SECN+ | Neville Arena · Auburn, AL |
| 2 | Thu Nov 6 | vsMerrimack | W95-57 | 2-0 | 1.000 | #20 | SECN+ | Neville Arena · Auburn, AL |
| 3 | Tue Nov 11 | vsWofford | W93-62 | 3-0 | 1.000 | #22 | SECN+ | Neville Arena · Auburn, AL |
| 4 | Sun Nov 16 | vs1Houston | L72-73 | 3-1 | .750 | #22 | ESPN | Neville Arena · Auburn, AL |
| 5 | Wed Nov 19 | vsJackson St | W112-66 | 4-1 | .800 | #22 | SEC Network | Neville Arena · Auburn, AL |
| 6 | Mon Nov 24 | atOregon | W84-73 | 5-1 | .833 | #21 | truTV | Matthew Knight Arena · Eugene, OR |
| 7 | Tue Nov 25 | at7Michigan | L72-102 | 5-2 | .714 | #21 | TNT | Crisler Center · Ann Arbor, MI |
| 8 | Wed Nov 26 | vs14St John's | W85-74 | 6-2 | .750 | #21 | truTV | Neville Arena · Auburn, AL |
| 9 | Wed Dec 3 | vsNC State | W83-73 | 7-2 | .778 | #20 | ESPN | Neville Arena · Auburn, AL |
| 10 | Sat Dec 6 | at2Arizona | L68-97 | 7-3 | .700 | #20 | ESPN | McKale Center · Tucson, AZ |
| 11 | Sat Dec 13 | vsChattanooga | W92-78 | 8-3 | .727 | #21 | SEC Network | State Farm Arena · Atlanta, GA |
| 12 | Sat Dec 20 | at6Purdue | L60-88 | 8-4 | .667 | #21 | Peacock | Mackey Arena · West Lafayette, IN |
| 13 | Mon Dec 29 | vsQueens | W106-65 | 9-4 | .692 | - | SEC Network | Neville Arena · Auburn, AL |
| 14 | Sat Jan 3 | at23Georgia | L100-104 (OT) | 9-5 | .643 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 15 | Tue Jan 6 | vsTexas A&M | L88-90 | 9-6 | .600 | - | SEC Network | Neville Arena · Auburn, AL |
| 16 | Sat Jan 10 | vs15Arkansas | W95-73 | 10-6 | .625 | - | ESPN | Neville Arena · Auburn, AL |
| 17 | Wed Jan 14 | atMissouri | L74-84 | 10-7 | .588 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 18 | Sat Jan 17 | vsSouth Carolina | W71-67 | 11-7 | .611 | - | SEC Network | Neville Arena · Auburn, AL |
| 19 | Tue Jan 20 | atOle Miss | W78-66 | 12-7 | .632 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 20 | Sat Jan 24 | at16Florida | W76-67 | 13-7 | .650 | - | ESPN | O'Connell Center · Gainesville, FL |
| 21 | Wed Jan 28 | vsTexas | W88-82 | 14-7 | .667 | - | ESPN2 | Neville Arena · Auburn, AL |
| 22 | Sat Jan 31 | atTennessee | L69-77 | 14-8 | .636 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 7 | vsAlabama | L92-96 | 14-9 | .609 | - | ESPN2 | Neville Arena · Auburn, AL |
| 24 | Tue Feb 10 | vs19Vanderbilt | L76-84 | 14-10 | .583 | - | SEC Network | Neville Arena · Auburn, AL |
| 25 | Sat Feb 14 | at21Arkansas | L75-88 | 14-11 | .560 | - | ESPN | Bud Walton Arena · Fayetteville, AR |
| 26 | Wed Feb 18 | atMississippi St | L85-91 | 14-12 | .538 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 21 | vsKentucky | W75-74 | 15-12 | .556 | - | ESPN | Neville Arena · Auburn, AL |
| 28 | Tue Feb 24 | atOklahoma | L79-91 | 15-13 | .536 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 29 | Sat Feb 28 | vsOle Miss | L79-85 | 15-14 | .517 | - | SEC Network | Neville Arena · Auburn, AL |
