| 1 | Wed Nov 6 | vs Vermont | W94-43 | 1-0 | 1.000 | #11 | ESPN+ | Neville Arena · Auburn, AL |
| 2 | Sat Nov 9 | at #4Houston | W74-69 | 2-0 | 1.000 | #11 | ESPNU | Fertitta Center · Houston, TX |
| 3 | Wed Nov 13 | vs Kent State | W79-56 | 3-0 | 1.000 | #5 | ESPN+ | Neville Arena · Auburn, AL |
| 4 | Mon Nov 18 | vs North Alabama | W102-69 | 4-0 | 1.000 | #4 | SEC Network | Neville Arena · Auburn, AL |
| 5 | Mon Nov 25 | at #5Iowa State | W83-81 | 5-0 | 1.000 | #4 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 6 | Tue Nov 26 | at #12UNC | W85-72 | 6-0 | 1.000 | #4 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Wed Nov 27 | vs Memphis | W90-76 | 7-0 | 1.000 | #4 | ESPN | Neville Arena · Auburn, AL |
| 8 | Wed Dec 4 | at #9Duke | L78-84 | 7-1 | .875 | #2 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 9 | Sun Dec 8 | vs Richmond | W98-54 | 8-1 | .889 | #2 | SEC Network | Neville Arena · Auburn, AL |
| 10 | Sat Dec 14 | vs Ohio State | W91-53 | 9-1 | .900 | #2 | ESPN2 | Neville Arena · Auburn, AL |
| 11 | Tue Dec 17 | vs Georgia St | W100-59 | 10-1 | .909 | #2 | ESPN+ | Neville Arena · Auburn, AL |
| 12 | Sat Dec 21 | vs #16Purdue | W87-69 | 11-1 | .917 | #2 | ESPN | Neville Arena · Auburn, AL |
| 13 | Mon Dec 30 | vs Monmouth | W87-58 | 12-1 | .923 | #2 | ESPN+ | Neville Arena · Auburn, AL |
| 14 | Sat Jan 4 | vs Missouri | W84-68 | 13-1 | .929 | #2 | SEC Network | Neville Arena · Auburn, AL |
| 15 | Tue Jan 7 | at Texas | W87-82 | 14-1 | .933 | #2 | ESPN2 | Moody Center · Austin, TX |
| 16 | Sat Jan 11 | at South Carolina | W66-63 | 15-1 | .938 | #2 | SEC Network | Colonial Life Arena · Columbia, SC |
| 17 | Tue Jan 14 | vs #15Mississippi St | W88-66 | 16-1 | .941 | #1 | SEC Network | Neville Arena · Auburn, AL |
| 18 | Sat Jan 18 | at #23Georgia | W70-68 | 17-1 | .944 | #1 | SEC Network | Stegeman Coliseum · Athens, GA |
| 19 | Sat Jan 25 | vs #6Tennessee | W53-51 | 18-1 | .947 | #1 | ESPN | Neville Arena · Auburn, AL |
| 20 | Wed Jan 29 | at LSU | W87-74 | 19-1 | .950 | #1 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 21 | Sat Feb 1 | at #23Ole Miss | W92-82 | 20-1 | .952 | #1 | ESPN | SJB Pavilion · Oxford, MS |
| 22 | Tue Feb 4 | vs Oklahoma | W98-70 | 21-1 | .955 | #1 | SEC Network | Neville Arena · Auburn, AL |
| 23 | Sat Feb 8 | vs #6Florida | L81-90 | 21-2 | .913 | #1 | ESPN2 | Neville Arena · Auburn, AL |
| 24 | Tue Feb 11 | at Vanderbilt | W80-68 | 22-2 | .917 | #1 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 15 | at #2Alabama | W94-85 | 23-2 | .920 | #1 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 26 | Wed Feb 19 | vs Arkansas | W67-60 | 24-2 | .923 | #1 | ESPN | Neville Arena · Auburn, AL |
#17Kentucky
#7Texas A&M