| 1 | Mon Nov 7 | vs George Mason | W70-52 | 1-0 | 1.000 | #15 | | Neville Arena · Auburn, AL |
| 2 | Fri Nov 11 | vs South Florida | W67-59 | 2-0 | 1.000 | #15 | | Neville Arena · Auburn, AL |
| 3 | Tue Nov 15 | vs Winthrop | W89-65 | 3-0 | 1.000 | #13 | SEC Network | Neville Arena · Auburn, AL |
| 4 | Fri Nov 18 | vs Texas So | W72-56 | 4-0 | 1.000 | #13 | | Neville Arena · Auburn, AL |
| 5 | Tue Nov 22 | vs Bradley | W85-64 | 5-0 | 1.000 | - | CBS | Neville Arena · Auburn, AL |
| 6 | Wed Nov 23 | at Northwestern | W43-42 | 6-0 | 1.000 | - | CBS | Welsh-Ryan Arena · Evanston, IL |
| 7 | Sun Nov 27 | vs Saint Louis | W65-60 | 7-0 | 1.000 | #13 | SEC Network | Neville Arena · Auburn, AL |
| 8 | Fri Dec 2 | vs Colgate | W93-66 | 8-0 | 1.000 | #15 | | Neville Arena · Auburn, AL |
| 9 | Sat Dec 10 | at Memphis | L73-82 | 8-1 | .889 | - | ESPN2 | FedExForum · Memphis, TN |
| 10 | Wed Dec 14 | vs Georgia St | W72-64 | 9-1 | .900 | #19 | | Neville Arena · Auburn, AL |
| 11 | Sun Dec 18 | at USC | L71-74 | 9-2 | .818 | #19 | ESPN | Galen Center · Los Angeles, CA |
| 12 | Wed Dec 21 | at Washington | W84-61 | 10-2 | .833 | #23 | PACN | Alaska Airlines Arena · Seattle, WA |
| 13 | Wed Dec 28 | vs Florida | W61-58 | 11-2 | .846 | #20 | ESPN2 | Neville Arena · Auburn, AL |
| 14 | Wed Jan 4 | at Georgia | L64-76 | 11-3 | .786 | #22 | SEC Network | Stegeman Coliseum · Athens, GA |
| 15 | Sat Jan 7 | vs #13Arkansas | W72-59 | 12-3 | .800 | #22 | SEC Network | Neville Arena · Auburn, AL |
| 16 | Tue Jan 10 | at Ole Miss | W82-73 | 13-3 | .813 | #21 | ESPNU | SJB Pavilion · Oxford, MS |
| 17 | Sat Jan 14 | vs Mississippi St | W69-63 | 14-3 | .824 | #21 | SEC Network | Neville Arena · Auburn, AL |
| 18 | Wed Jan 18 | at LSU | W67-49 | 15-3 | .833 | #16 | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 19 | Sat Jan 21 | at South Carolina | W81-66 | 16-3 | .842 | #16 | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Wed Jan 25 | vs Texas A&M | L63-79 | 16-4 | .800 | #15 | ESPN2 | Neville Arena · Auburn, AL |
| 21 | Sat Jan 28 | at West Virginia | L77-80 | 16-5 | .762 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 22 | Wed Feb 1 | vsGeorgia | W94-73 | 17-5 | .773 | #25 | SEC Network | Neville Arena · Auburn, AL |
| 23 | Sat Feb 4 | at #2Tennessee | L43-46 | 17-6 | .739 | #25 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 24 | Tue Feb 7 | atTexas A&M | L78-83 | 17-7 | .708 | - | ESPN2 | Reed Arena · College Station, TX |
| 25 | Sat Feb 11 | vs #3Alabama | L69-77 | 17-8 | .680 | - | ESPN | Neville Arena · Auburn, AL |
| 26 | Tue Feb 14 | vs Missouri | W89-56 | 18-8 | .692 | - | ESPN2 | Neville Arena · Auburn, AL |
| 27 | Sat Feb 18 | at Vanderbilt | L65-67 | 18-9 | .667 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Wed Feb 22 | vsOle Miss | W78-74 | 19-9 | .679 | - | SEC Network | Neville Arena · Auburn, AL |
| 29 | Sat Feb 25 | at Kentucky | L54-86 | 19-10 | .655 | - | CBS | Rupp Arena · Lexington, KY |
| 30 | Wed Mar 1 | at#2Alabama | L85-90 (OT) | 19-11 | .633 | - | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 31 | Sat Mar 4 | vs#12Tennessee | W79-70 | 20-11 | .645 | - | ESPN | Neville Arena · Auburn, AL |
| 32 | Thu Mar 9 | vsArkansas | L73-76 | 20-12 | .625 | - | SEC Network | Neville Arena · Auburn, AL |
| 33 | Thu Mar 16 | at #8Iowa | W83-75 | 21-12 | .636 | #9 | TNT | Carver-Hawkeye Arena · Iowa City, IA |
| 34 | Sat Mar 18 | at #1Houston | L64-81 | 21-13 | .618 | #9 | TBS | Fertitta Center · Houston, TX |
