| 1 | Mon Nov 4 | vs Long Island | W90-60 | 1-0 | 1.000 | #24 | ESPN+ | SJB Pavilion · Oxford, MS |
| 2 | Fri Nov 8 | vs Grambling | W66-64 | 22-11 | .667 | #24 | SEC Network | SJB Pavilion · Oxford, MS |
| 3 | Tue Nov 12 | vs South Alabama | W64-54 | 3-0 | 1.000 | #25 | ESPN+ | SJB Pavilion · Oxford, MS |
| 4 | Sat Nov 16 | vs Colorado St | W84-69 | 4-0 | 1.000 | #25 | ESPN+ | SJB Pavilion · Oxford, MS |
| 5 | Thu Nov 21 | vs Oral Roberts | W100-68 | 5-0 | 1.000 | - | ESPN+ | SJB Pavilion · Oxford, MS |
| 6 | Thu Nov 28 | vs BYU | W96-85 (OT) | 6-0 | 1.000 | #23 | FS1 | SJB Pavilion · Oxford, MS |
| 7 | Fri Nov 29 | at #13Purdue | L78-80 | 6-1 | .857 | #23 | | Mackey Arena · West Lafayette, IN |
| 8 | Tue Dec 3 | at Louisville | W86-63 | 7-1 | .875 | #23 | ACC Network | KFC Yum! Center · Louisville, KY |
| 9 | Sat Dec 7 | vs Lindenwood | W86-53 | 8-1 | .889 | #23 | ESPN+ | SJB Pavilion · Oxford, MS |
| 10 | Sat Dec 14 | vs Southern Miss | W77-46 | 9-1 | .900 | #19 | SECN+ | SJB Pavilion · Oxford, MS |
| 11 | Tue Dec 17 | vs Southern | W74-61 | 10-1 | .909 | #17 | ESPN+ | SJB Pavilion · Oxford, MS |
| 12 | Sat Dec 21 | vs Queens | W80-62 | 11-1 | .917 | #17 | ESPN+ | SJB Pavilion · Oxford, MS |
| 13 | Sat Dec 28 | at Memphis | L70-87 | 11-2 | .846 | #16 | ESPN2 | FedExForum · Memphis, TN |
| 14 | Sat Jan 4 | vs Georgia | W63-51 | 12-2 | .857 | #24 | SEC Network | SJB Pavilion · Oxford, MS |
| 15 | Wed Jan 8 | at Arkansas | W73-66 | 13-2 | .867 | #23 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 16 | Sat Jan 11 | vs LSU | W77-65 | 14-2 | .875 | #23 | SEC Network | SJB Pavilion · Oxford, MS |
| 17 | Tue Jan 14 | at #4Alabama | W74-64 | 15-2 | .882 | #21 | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 18 | Sat Jan 18 | at #15Mississippi St | L81-84 (OT) | 15-3 | .833 | #21 | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 19 | Wed Jan 22 | vs #13Texas A&M | L62-63 | 15-4 | .789 | #16 | ESPN2 | SJB Pavilion · Oxford, MS |
| 20 | Sat Jan 25 | at #22Missouri | L75-83 | 15-5 | .750 | #16 | SEC Network | Mizzou Arena · Columbia, MO |
| 21 | Wed Jan 29 | vs Texas | W72-69 | 16-5 | .762 | #23 | ESPN2 | SJB Pavilion · Oxford, MS |
| 22 | Sat Feb 1 | vs #1Auburn | L82-92 | 16-6 | .727 | #23 | ESPN | SJB Pavilion · Oxford, MS |
| 23 | Tue Feb 4 | vs #14Kentucky | W98-84 | 17-6 | .739 | #25 | ESPN | SJB Pavilion · Oxford, MS |
| 24 | Sat Feb 8 | atLSU | W72-70 | 18-6 | .750 | #25 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 25 | Wed Feb 12 | at South Carolina | W72-68 | 19-6 | .760 | #19 | SEC Network | Colonial Life Arena · Columbia, SC |
| 26 | Sat Feb 15 | vs#22Mississippi St | L71-81 | 19-7 | .731 | #19 | ESPN2 | SJB Pavilion · Oxford, MS |
| 27 | Sat Feb 22 | at Vanderbilt | L72-77 | 19-8 | .704 | #24 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Wed Feb 26 | at#1Auburn | L76-106 | 19-9 | .679 | - | ESPN2 | Neville Arena · Auburn, AL |
| 29 | Sat Mar 1 | vs Oklahoma | W87-84 | 20-9 | .690 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 30 | Wed Mar 5 | vs #4Tennessee | W78-76 | 21-9 | .700 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 31 | Sat Mar 8 | at #5Florida | L71-90 | 21-10 | .677 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 32 | Thu Mar 13 | vsArkansas | W83-80 | 22-10 | .688 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 33 | Fri Mar 14 | at#3Auburn | L57-62 | 22-11 | .667 | - | ESPN | Neville Arena · Auburn, AL |
| 34 | Fri Mar 21 | vs #11UNC | W71-64 | 23-11 | .676 | #6 | TNT | SJB Pavilion · Oxford, MS |
| 35 | Sun Mar 23 | at #3Iowa State | W91-78 | 24-11 | .686 | #6 | truTV | James H. Hilton Coliseum · Ames, IA |
#2Michigan St