| 1 | Fri Nov 8 | vs Arkansas St | W71-43 | 1-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 2 | Tue Nov 12 | vsNorfolk St | W68-55 | 2-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 3 | Fri Nov 15 | vsW Michigan | W85-58 | 3-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 4 | Tue Nov 19 | vsSeattle U | W65-52 | 4-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 5 | Sat Nov 23 | at16Memphis | L86-87 | 4-1 | .800 | - | | FedExForum · Memphis, TN |
| 6 | Wed Nov 27 | atPenn State | W74-72 | 5-1 | .833 | - | ESPN2 | Bryce Jordan Center · University Park, PA |
| 7 | Fri Nov 29 | atOklahoma St | L37-78 | 5-2 | .714 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Tue Dec 3 | vs24Butler | L58-67 | 5-3 | .625 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 9 | Sat Dec 7 | vsBakersfield | W83-67 | 6-3 | .667 | - | | SJB Pavilion · Oxford, MS |
| 10 | Sat Dec 14 | vsMTSU | W82-64 | 7-3 | .700 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 11 | Sat Dec 21 | vsSE Louisiana | W83-76 | 8-3 | .727 | - | | University Center (LA) · Hammond, LA |
| 12 | Sun Dec 29 | vsTennessee Tech | W80-63 | 9-3 | .750 | - | | SJB Pavilion · Oxford, MS |
| 13 | Sat Jan 4 | at24Wichita St | L54-74 | 9-4 | .692 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 14 | Tue Jan 7 | atTexas A&M | L47-57 | 9-5 | .643 | - | SEC Network | Reed Arena · College Station, TX |
| 15 | Sat Jan 11 | vsArkansas | L72-76 | 9-6 | .600 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 16 | Tue Jan 14 | atFlorida | L55-71 | 9-7 | .563 | - | ESPN2 | O'Connell Center · Gainesville, FL |
| 17 | Sat Jan 18 | vsLSU | L76-80 | 9-8 | .529 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 18 | Tue Jan 21 | atTennessee | L48-73 | 9-9 | .500 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 19 | Sat Jan 25 | atGeorgia | W70-60 | 10-9 | .526 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 20 | Tue Jan 28 | vs17Auburn | L82-83 (2OT) | 10-10 | .500 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 21 | Sat Feb 1 | at22LSU | L63-73 | 10-11 | .476 | - | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 22 | Wed Feb 5 | vsSouth Carolina | W84-70 | 11-11 | .500 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 23 | Sat Feb 8 | vsFlorida | W68-51 | 12-11 | .522 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 24 | Tue Feb 11 | vsMississippi St | W83-58 | 13-11 | .542 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 25 | Sat Feb 15 | at12Kentucky | L62-67 | 13-12 | .520 | - | ESPN | Rupp Arena · Lexington, KY |
| 26 | Tue Feb 18 | atMissouri | L68-71 | 13-13 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 22 | vsAlabama | L78-103 | 13-14 | .481 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 28 | Tue Feb 25 | at15Auburn | L58-67 | 13-15 | .464 | - | SEC Network | Neville Arena · Auburn, AL |
| 29 | Sat Feb 29 | vsVanderbilt | W86-60 | 14-15 | .483 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 30 | Wed Mar 4 | vsMissouri | W75-67 | 15-15 | .500 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 31 | Sat Mar 7 | atMississippi St | L44-69 | 15-16 | .484 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 32 | Wed Mar 11 | vsGeorgia | L63-81 | 15-17 | .469 | - | SEC Network | SJB Pavilion · Oxford, MS |
