| 1 | Mon Nov 6 | vs Alabama St | W69-59 | 1-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 2 | Fri Nov 10 | vsE Washington | W75-64 | 2-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 3 | Tue Nov 14 | vsDetroit Mercy | W70-69 | 3-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 4 | Fri Nov 17 | vsSam Houston | W70-67 | 4-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 5 | Wed Nov 22 | atTemple | W77-76 | 5-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 6 | Tue Nov 28 | vsNC State | W72-52 | 6-0 | 1.000 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 7 | Sat Dec 2 | vsMemphis | W80-77 | 7-0 | 1.000 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 8 | Tue Dec 5 | vsMount St Mary | W77-68 | 8-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 9 | Sun Dec 10 | atUCF | W70-68 | 9-0 | 1.000 | - | | Addition Financial Arena · Orlando, FL |
| 10 | Sat Dec 16 | vsCalifornia | W88-78 | 10-0 | 1.000 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 11 | Tue Dec 19 | vsTroy | W74-53 | 11-0 | 1.000 | #25 | | SJB Pavilion · Oxford, MS |
| 12 | Sat Dec 23 | vsSouthern Miss | W89-72 | 12-0 | 1.000 | #25 | | SJB Pavilion · Oxford, MS |
| 13 | Sun Dec 31 | vsBryant | W95-78 | 13-0 | 1.000 | #24 | SEC Network | SJB Pavilion · Oxford, MS |
| 14 | Sat Jan 6 | at5Tennessee | L64-90 | 13-1 | .929 | #22 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 15 | Wed Jan 10 | vsFlorida | W103-85 | 14-1 | .933 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 16 | Sat Jan 13 | vsVanderbilt | W69-56 | 15-1 | .938 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 17 | Wed Jan 17 | atLSU | L80-89 | 15-2 | .882 | #22 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 18 | Sat Jan 20 | at13Auburn | L59-82 | 15-3 | .833 | #22 | SEC Network | Neville Arena · Auburn, AL |
| 19 | Wed Jan 24 | vsArkansas | W77-51 | 16-3 | .842 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 20 | Sat Jan 27 | atTexas A&M | W71-68 | 17-3 | .850 | - | SEC Network | Reed Arena · College Station, TX |
| 21 | Tue Jan 30 | vsMississippi St | W86-82 | 18-3 | .857 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 22 | Sat Feb 3 | vs16Auburn | L77-91 | 18-4 | .818 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 23 | Tue Feb 6 | at15South Carolina | L65-68 | 18-5 | .783 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 24 | Tue Feb 13 | at22Kentucky | L63-75 | 18-6 | .750 | - | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 17 | vsMissouri | W79-76 | 19-6 | .760 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 26 | Wed Feb 21 | atMississippi St | L71-83 | 19-7 | .731 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 24 | vs20South Carolina | L59-72 | 19-8 | .704 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 28 | Wed Feb 28 | vs14Alabama | L88-103 | 19-9 | .679 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 29 | Sat Mar 2 | atMissouri | W84-78 | 20-9 | .690 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 30 | Tue Mar 5 | atGeorgia | L66-69 | 20-10 | .667 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 31 | Sat Mar 9 | vsTexas A&M | L60-86 | 20-11 | .645 | - | CBS | SJB Pavilion · Oxford, MS |
| 32 | Thu Mar 14 | atTexas A&M | L71-80 | 20-12 | .625 | - | SEC Network | Reed Arena · College Station, TX |
