| 1 | Mon Nov 3 | vs SE Louisiana | W88-58 | 1-0 | 1.000 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 2 | Fri Nov 7 | vsUL Monroe | W86-65 | 2-0 | 1.000 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 3 | Tue Nov 11 | vsMemphis | W83-77 | 3-0 | 1.000 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 4 | Fri Nov 14 | vsBakersfield | W82-60 | 4-0 | 1.000 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 5 | Tue Nov 18 | vsAustin Peay | W72-65 | 5-0 | 1.000 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 6 | Tue Nov 25 | atIowa | L69-74 | 5-1 | .833 | - | CBSSN | Carver-Hawkeye Arena · Iowa City, IA |
| 7 | Wed Nov 26 | vsUtah | L74-75 | 5-2 | .714 | - | | SJB Pavilion · Oxford, MS |
| 8 | Tue Dec 2 | vsMiami | L66-75 | 5-3 | .625 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 9 | Sat Dec 6 | at23St John's | L58-63 | 5-4 | .556 | - | Peacock | Carnesecca Arena · Queens, NY |
| 10 | Sat Dec 13 | vsSouthern Miss | W71-67 | 6-4 | .600 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 11 | Wed Dec 17 | vsAlabama A&M | W80-66 | 7-4 | .636 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 12 | Sun Dec 21 | atNC State | L62-76 | 7-5 | .583 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 13 | Mon Dec 29 | vsAlcorn St | W79-43 | 8-5 | .615 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 14 | Sat Jan 3 | atOklahoma | L70-86 | 8-6 | .571 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 15 | Wed Jan 7 | vs15Arkansas | L87-94 | 8-7 | .533 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 16 | Sat Jan 10 | vsMissouri | W76-69 | 9-7 | .563 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 17 | Wed Jan 14 | at21Georgia | W97-95 (OT) | 10-7 | .588 | - | ESPNU | Stegeman Coliseum · Athens, GA |
| 18 | Sat Jan 17 | atMississippi St | W68-67 | 11-7 | .611 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 19 | Tue Jan 20 | vsAuburn | L66-78 | 11-8 | .579 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 20 | Sat Jan 24 | atKentucky | L63-72 | 11-9 | .550 | - | ESPN | Rupp Arena · Lexington, KY |
| 21 | Sat Jan 31 | at18Vanderbilt | L68-71 | 11-10 | .524 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Tue Feb 3 | at25Tennessee | L66-84 | 11-11 | .500 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 7 | atTexas | L68-79 | 11-12 | .478 | - | ESPN2 | Moody Center · Austin, TX |
| 24 | Wed Feb 11 | vsAlabama | L74-93 | 11-13 | .458 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 25 | Sat Feb 14 | vsMississippi St | L78-90 | 11-14 | .440 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 26 | Wed Feb 18 | atTexas A&M | L77-80 | 11-15 | .423 | - | SEC Network | Reed Arena · College Station, TX |
| 27 | Sat Feb 21 | vs12Florida | L75-94 | 11-16 | .407 | - | ESPN | SJB Pavilion · Oxford, MS |
| 28 | Wed Feb 25 | vsLSU | L99-106 (2OT) | 11-17 | .393 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 29 | Sat Feb 28 | atAuburn | W85-79 | 12-17 | .414 | - | SEC Network | Neville Arena · Auburn, AL |
