| 1 | Mon Nov 7 | vs Alcorn St | W73-58 | 1-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 2 | Fri Nov 11 | vsFAU | W80-67 | 2-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 3 | Tue Nov 15 | vsChattanooga | W70-58 | 3-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 4 | Fri Nov 18 | vsUT Martin | W72-68 | 4-0 | 1.000 | - | | SJB Pavilion · Oxford, MS |
| 5 | Thu Nov 24 | atStanford | W72-68 | 5-0 | 1.000 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 6 | Fri Nov 25 | vsSiena | W74-62 | 6-0 | 1.000 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 7 | Sun Nov 27 | atOklahoma | L55-59 | 6-1 | .857 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 8 | Sat Dec 3 | atMemphis | L57-68 | 6-2 | .750 | - | ESPN2 | FedExForum · Memphis, TN |
| 9 | Sat Dec 10 | vsValparaiso | W98-61 | 7-2 | .778 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 10 | Wed Dec 14 | vsUCF | L61-72 | 7-3 | .700 | - | | SJB Pavilion · Oxford, MS |
| 11 | Sat Dec 17 | vsTemple | W63-55 | 8-3 | .727 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 12 | Tue Dec 20 | vsNorth Alabama | L65-66 | 8-4 | .667 | - | | SJB Pavilion · Oxford, MS |
| 13 | Wed Dec 28 | vs7Tennessee | L59-63 | 8-5 | .615 | - | ESPNEWS | SJB Pavilion · Oxford, MS |
| 14 | Tue Jan 3 | at7Alabama | L62-84 | 8-6 | .571 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Sat Jan 7 | atMississippi St | L54-64 | 8-7 | .533 | - | CBS | Humphrey Coliseum · Starkville, MS |
| 16 | Tue Jan 10 | vs21Auburn | L73-82 | 8-8 | .500 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 17 | Sat Jan 14 | vsGeorgia | L58-62 | 8-9 | .471 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 18 | Tue Jan 17 | atSouth Carolina | W70-58 | 9-9 | .500 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 19 | Sat Jan 21 | at25Arkansas | L57-69 | 9-10 | .474 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 20 | Tue Jan 24 | vsMissouri | L77-89 | 9-11 | .450 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 21 | Sat Jan 28 | atOklahoma St | L60-82 | 9-12 | .429 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Tue Jan 31 | vsKentucky | L66-75 | 9-13 | .409 | - | ESPN | SJB Pavilion · Oxford, MS |
| 23 | Sat Feb 4 | atVanderbilt | L71-74 | 9-14 | .391 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 24 | Tue Feb 7 | atGeorgia | W78-74 | 10-14 | .417 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 25 | Sat Feb 11 | vsSouth Carolina | L61-64 | 10-15 | .400 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 26 | Wed Feb 15 | atFlorida | L64-79 | 10-16 | .385 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 27 | Sat Feb 18 | vsMississippi St | L61-69 (OT) | 10-17 | .370 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 28 | Wed Feb 22 | atAuburn | L74-78 | 10-18 | .357 | - | SEC Network | Neville Arena · Auburn, AL |
| 29 | Sat Feb 25 | vsLSU | W82-69 | 11-18 | .379 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 30 | Tue Feb 28 | vs24Texas A&M | L61-69 | 11-19 | .367 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 31 | Sat Mar 4 | atMissouri | L77-82 | 11-20 | .355 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 32 | Wed Mar 8 | atSouth Carolina | W67-61 | 12-20 | .375 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 33 | Thu Mar 9 | atTennessee | L55-70 | 12-21 | .364 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
