| 4 | Thu Dec 10 | vs Jackson St | W80-45 | 1-0 | 1.000 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 5 | Sat Dec 12 | vsUNC Wilmington | W78-58 | 2-0 | 1.000 | - | SEC Alternate | SJB Pavilion · Oxford, MS |
| 6 | Mon Dec 14 | vsC Arkansas | W68-54 | 3-0 | 1.000 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 7 | Wed Dec 16 | atMTSU | W70-51 | 4-0 | 1.000 | - | CBSSN | Murphy Center · Murfreesboro, TN |
| 8 | Sat Dec 19 | atDayton | L62-65 | 4-1 | .800 | - | NBCSN | UD Arena · Dayton, OH |
| 9 | Tue Dec 22 | vsUT Martin | W90-43 | 5-1 | .833 | - | | SJB Pavilion · Oxford, MS |
| 10 | Tue Dec 29 | atAlabama | L64-82 | 5-2 | .714 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 11 | Sat Jan 2 | vsWichita St | L79-83 | 5-3 | .625 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 12 | Wed Jan 6 | vsAuburn | W72-61 | 6-3 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 13 | Sat Jan 9 | vsLSU | L61-75 | 6-4 | .600 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 14 | Tue Jan 12 | atFlorida | L63-72 | 6-5 | .545 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 15 | Sat Jan 16 | vsGeorgia | L74-78 | 6-6 | .500 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 16 | Tue Jan 19 | atMississippi St | W64-46 | 7-6 | .538 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Sat Jan 23 | vsTexas A&M | W61-50 | 8-6 | .571 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 18 | Wed Jan 27 | atArkansas | L59-74 | 8-7 | .533 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 19 | Sat Jan 30 | atGeorgia | L61-71 | 8-8 | .500 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 20 | Tue Feb 2 | vs11Tennessee | W52-50 | 9-8 | .529 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 21 | Sat Feb 6 | atAuburn | W86-84 (OT) | 10-8 | .556 | - | ESPN2 | Neville Arena · Auburn, AL |
| 22 | Wed Feb 10 | vs10Missouri | W80-59 | 11-8 | .579 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 23 | Sat Feb 13 | atSouth Carolina | W81-74 | 12-8 | .600 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 25 | Sat Feb 20 | vsMississippi St | L56-66 | 12-9 | .571 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 26 | Tue Feb 23 | at24Missouri | W60-53 | 13-9 | .591 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 27 | atVanderbilt | L70-75 | 13-10 | .565 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Tue Mar 2 | vsKentucky | W70-62 | 14-10 | .583 | - | ESPN | SJB Pavilion · Oxford, MS |
| 29 | Sat Mar 6 | vsVanderbilt | W56-46 | 15-10 | .600 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 30 | Thu Mar 11 | vsSouth Carolina | W76-59 | 16-10 | .615 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 31 | Fri Mar 12 | atLSU | L73-76 | 16-11 | .593 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 28 | Fri Mar 19 | vs4Louisiana Tech | L61-70 | 16-12 | .571 | #1 | ESPN2 | SJB Pavilion · Oxford, MS |
