| 1 | Mon Nov 4 | vs Bowling Green | W77-68 | 1-0 | 1.000 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 2 | Thu Nov 7 | at UAB | L84-98 | 1-1 | .500 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 3 | Tue Nov 12 | vs TBD | W104-65 | 2-1 | .667 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 4 | Wed Nov 20 | at S Dakota St | L76-101 | 2-2 | .500 | - | | Frost Arena · Brookings, SD |
| 5 | Sun Nov 24 | at Montana St | L59-79 | 2-3 | .400 | - | ESPN+ | Worthington Arena · Bozeman, MT |
| 6 | Mon Nov 25 | vs Abilene Chrstn | L74-82 | 2-4 | .333 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Sat Nov 30 | vs Milwaukee | W66-65 | 3-4 | .429 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 8 | Thu Dec 5 | vs Alabama St | W81-64 | 4-4 | .500 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 9 | Tue Dec 10 | at Tulane | L58-86 | 4-5 | .444 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 10 | Sat Dec 14 | at #19Ole Miss | L46-77 | 4-6 | .400 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 11 | Tue Dec 17 | vs Lamar | L65-69 | 4-7 | .364 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 12 | Sat Dec 21 | vs Marshall | W68-66 | 5-7 | .417 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 13 | Mon Dec 30 | vsTBD | W80-70 | 6-7 | .462 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 14 | Thu Jan 2 | at JMU | L72-83 | 6-8 | .429 | - | ESPN+ | Atlantic Union Bank Center · Harrisonburg, VA |
| 15 | Sat Jan 4 | at Old Dominion | L71-74 | 6-9 | .400 | - | ESPN+ | Chartway Arena · Norfolk, VA |
| 16 | Thu Jan 9 | vs UL Monroe | W84-67 | 7-9 | .438 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 17 | Sat Jan 11 | vs Texas St | W92-88 (OT) | 8-9 | .471 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 18 | Wed Jan 15 | at South Alabama | L62-75 | 8-10 | .444 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 19 | Sat Jan 18 | atTexas St | L82-85 (OT) | 8-11 | .421 | - | ESPN+ | Strahan Arena at the University Events Center · San Marcos, TX |
| 20 | Sat Jan 25 | at Louisiana | W67-59 | 9-11 | .450 | - | ESPN+ | Cajundome · Lafayette, LA |
| 21 | Mon Jan 27 | at Troy | L61-70 | 9-12 | .429 | - | ESPN+ | Trojan Arena · Troy, AL |
| 22 | Wed Jan 29 | vs Arkansas St | L68-81 | 9-13 | .409 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 23 | Sat Feb 1 | vs Georgia So | W72-68 | 10-13 | .435 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 24 | Wed Feb 5 | at Appalachian St | L58-60 | 10-14 | .417 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 25 | Sat Feb 8 | at Ball State | L76-77 | 10-15 | .400 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 26 | Wed Feb 12 | atArkansas St | L67-101 | 10-16 | .385 | - | ESPN+ | First National Bank Arena · Jonesboro, AR |
| 27 | Sat Feb 15 | atUL Monroe | L74-81 | 10-17 | .370 | - | ESPN+ | Fant-Ewing Coliseum · Monroe, LA |
| 28 | Thu Feb 20 | vs Coast Car | L78-87 | 10-18 | .357 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
